Izvorni znanstveni članak

https://doi.org/10.24869/psyd.2017.179

VITAMIN D LEVELS AND VITAMIN D RECEPTOR GENE POLYMORPHISM IN MAJOR DEPRESSION

Merve Şahin Can orcid.org/0000-0002-4985-5689 ; Hopa State Hospital, Department of Psychiatry, Artvin, Turkey
Hayriye Baykan ; Balıkesir University School of Medicine, Department of Psychiatry, Balıkesir, Turkey
Özgür Baykan ; Ataturk State Hospital, Biochemistry Laboratory, Balıkesir, Turkey
Nevin Erensoy ; Balıkesir University School of Medicine, Department of Medical Biology, Balıkesir, Turkey
Tunay Karlıdere ; Balıkesir University School of Medicine, Department of Psychiatry, Balıkesir, Turkey

Sažetak

Background: The aim of this study is to evaluate vitamin D levels and rs2228570 (FokI) polymorphism of vitamin D in patients
with established diagnosis of major depressive disorder in order to investigate the impact of vitamin D levels and genetic
polymorphisms on etiology and/or severity of the disease.
Subjects and methods: The study included 86 patients who were diagnosed with major depressive disorder in Hospital of
Balıkesir University Faculty of Medicine, Department of Psychiatry, and 89 healthy volunteers with similar age, sex, education level
and BMI. Psychiatric diagnosis was established by using Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). For
clinical evaluation, sociodemographic data form, Hamilton Depression Rating Scale, Hamilton Anxiety Scale were used. Blood
samples were drawn after 12 hours of fasting from the patients volunteered and the control group who were given their informed
consent for participation in the study. Vitamin D levels were determined by using the method of ECLIA (Electrochemiluminescent
immunoassay). Genotype analysis was performed using the method of Polymerase Chain Reaction-Restriction Fragment Length
Polymorphism (PCR-RFLP).
Results: In our study, median vitamin D levels (min-max) of the patient and control groups were 10.3 ng/mL (3.0-42.1) and 11.4
ng/mL (3.0-38.8), respectively. Statistically significant differences as for vitamin D levels between groups were not detected
(p=0.729). Similiarly no statistically significant difference between groups in genotype distribution was observed (p=0.396).
Conclusion: In conclusion, our findings do not support the relationship between depression, vitamin D levels and Fok 1
polymorphism of vitamin D receptor. To test these hypotheses in the light of literature we need further studies to be performed with
large number of patients.

Ključne riječi

major depressive disorder (MDD); vitamin D; VDR

Hrčak ID:

184753

URI

https://hrcak.srce.hr/184753

Datum izdavanja:

28.6.2017.

Posjeta: 1.713 *