Ostalo
Comparison of doxycycline and benzathine penicillin G for the treatment of early syphilis
Hailu Xiao
; University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China
Dianchang Liu
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Zhen Li
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Rongtao Zheng
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Zhongwei Li
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Jianling Hou
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Shengjia Zhang
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Tongsheng Chu
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Hongqing Tian
; 1 University of Jinan-Shandong Academy of Medical Sciences, Jinan, Shandong, China 2 Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Furen Zhang
; Shandong Provincial Institute of Dermatology and Venereology, Jinan, Shandong, China
Sažetak
Doxycycline is the preferred recommended second-line treatment for the treatment of early syphilis. Recent reports showed a declining efficacy trend of doxycycline in treatment of early syphilis.The aim of our study was to assess the serological response to the treatment for early syphilis with doxycycline compared with benzathine penicillin G and evaluate whether doxycycline is still an effective agent for the treatment of early syphilis.A record-based retrospective study was conducted. Patients were diagnosed with early syphilis in an sexually transmitted disease (STD) clinic from January 1, 2008 to December 31, 2014. They were treated with a single dose of benzathine penicillin G 2.4MU or oral doxycycline 100 mg twice daily for 14 days. Pearson’s chi-squared test was used for data analysis. 601 cases were included in the final study sample: 105 (17.5%) patients received a 14-day course of doxycycline (doxycycline group), and 496 (82.5%) patients received single-dose benzathine penicillin G (BPG group). The serological responses at 6 months and 12 months after treatment were compared. No statistically significant differences were found between the two groups at 6 months (69.52% vs. 75.00%, P=0.245), and at 12 months (92.38% vs. 96.17%, P=0.115). Doxycycline is still an effective agent for the treatment of early syphilis.
Ključne riječi
Hrčak ID:
185016
URI
Datum izdavanja:
20.7.2017.
Posjeta: 1.389 *