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https://doi.org/10.5562/cca3146

Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives

Livio Racané ; Department of Applied Chemistry, Faculty of Textile Technology, University of Zagreb, Prilaz baruna Filipovića 28a, 10000 Zagreb, Croatia
Maja Cindrić ; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Nataša Perin ; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Petra Roškarić ; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia
Kristina Starčević ; Department of Animal Husbandry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia
Tomislav Mašek ; Department of Animal Nutrition and Dietetics, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
Maja Maurić ; Department of Animal Husbandry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, HR-10000 Zagreb, Croatia
Jasna Dogan ; Pliva – TAPI R&D Chemistry, Prilaz baruna Filipovića 29, 10000 Zagreb, Croatia
Grace Karminski-Zamola ; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 19, 10000 Zagreb, Croatia

Puni tekst: engleski, pdf (2 MB) str. 187-195 preuzimanja: 677* citiraj
APA 6th Edition
Racané, L., Cindrić, M., Perin, N., Roškarić, P., Starčević, K., Mašek, T., ... Karminski-Zamola, G. (2017). Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives. Croatica Chemica Acta, 90 (2), 187-195. https://doi.org/10.5562/cca3146
MLA 8th Edition
Racané, Livio, et al. "Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives." Croatica Chemica Acta, vol. 90, br. 2, 2017, str. 187-195. https://doi.org/10.5562/cca3146. Citirano 12.04.2021.
Chicago 17th Edition
Racané, Livio, Maja Cindrić, Nataša Perin, Petra Roškarić, Kristina Starčević, Tomislav Mašek, Maja Maurić, Jasna Dogan i Grace Karminski-Zamola. "Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives." Croatica Chemica Acta 90, br. 2 (2017): 187-195. https://doi.org/10.5562/cca3146
Harvard
Racané, L., et al. (2017). 'Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives', Croatica Chemica Acta, 90(2), str. 187-195. https://doi.org/10.5562/cca3146
Vancouver
Racané L, Cindrić M, Perin N, Roškarić P, Starčević K, Mašek T i sur. Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives. Croatica Chemica Acta [Internet]. 2017 [pristupljeno 12.04.2021.];90(2):187-195. https://doi.org/10.5562/cca3146
IEEE
L. Racané, et al., "Synthesis and Antioxidative Potency of Novel Amidino Substituted Benzimidazole and Benzothiazole Derivatives", Croatica Chemica Acta, vol.90, br. 2, str. 187-195, 2017. [Online]. https://doi.org/10.5562/cca3146

Sažetak
Herein we present the synthesis of versatile amidino substituted benzothiazole 3–10 and benzimidazole 12–19 derivatives substituted with the variable number of hydroxy and methoxy groups. Furthermore, the synthesized compounds were explored for their antioxidative activity in vitro by using three biological assays, namely DPPH, ABTS and FRAP. The obtained results indicated that the variable number of hydroxy groups together with the type of the amidino substituent strongly influenced the antioxidative activity and reducing power of tested compounds. The most promising antioxidative activity showed trihydroxy substituted compounds 6, 10, 15 and 19. In general, it was noticed that unsubstituted amidino group induced the more pronounced activity in comparison to derivatives bearing 2-imidazolinyl group.

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
amidines; benzimidazoles; benzothiazoles; antioxidative activity in vitro

Hrčak ID: 185031

URI
https://hrcak.srce.hr/185031

Posjeta: 968 *