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https://doi.org/10.5562/cca2937

Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity

Valentina Bušić ; Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Kuhačeva 20, HR-31000 Osijek, Croatia
Hrvoje Pavlović ; Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Kuhačeva 20, HR-31000 Osijek, Croatia
Sunčica Roca ; NMR Centre, Ruđer Bošković Institute, P. O. Box 180, HR-10002 Zagreb, Croatia
Dražen Vikić-Topić ; NMR Centre, Ruđer Bošković Institute, P. O. Box 180, HR-10002 Zagreb, Croatia
Dajana Gašo-Sokač ; Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Kuhačeva 20, HR-31000 Osijek, Croatia

Puni tekst: engleski, pdf (3 MB) str. 425-433 preuzimanja: 645* citiraj
APA 6th Edition
Bušić, V., Pavlović, H., Roca, S., Vikić-Topić, D. i Gašo-Sokač, D. (2017). Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity. Croatica Chemica Acta, 90 (3), 425-433. https://doi.org/10.5562/cca2937
MLA 8th Edition
Bušić, Valentina, et al. "Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity." Croatica Chemica Acta, vol. 90, br. 3, 2017, str. 425-433. https://doi.org/10.5562/cca2937. Citirano 21.09.2019.
Chicago 17th Edition
Bušić, Valentina, Hrvoje Pavlović, Sunčica Roca, Dražen Vikić-Topić i Dajana Gašo-Sokač. "Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity." Croatica Chemica Acta 90, br. 3 (2017): 425-433. https://doi.org/10.5562/cca2937
Harvard
Bušić, V., et al. (2017). 'Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity', Croatica Chemica Acta, 90(3), str. 425-433. https://doi.org/10.5562/cca2937
Vancouver
Bušić V, Pavlović H, Roca S, Vikić-Topić D, Gašo-Sokač D. Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity. Croatica Chemica Acta [Internet]. 2017 [pristupljeno 21.09.2019.];90(3):425-433. https://doi.org/10.5562/cca2937
IEEE
V. Bušić, H. Pavlović, S. Roca, D. Vikić-Topić i D. Gašo-Sokač, "Microwave-assisted Quaternization of Various Pyridine Derivatives and their Antibacterial Activity", Croatica Chemica Acta, vol.90, br. 3, str. 425-433, 2017. [Online]. https://doi.org/10.5562/cca2937

Sažetak
In this study, reactions of quaternization under microwave heating of pyridine, α-picoline, pyridine-4-aldoxime, pyridine-2-aldoxime, nicotinamide, isonicotinamide and pyridoxal oxime with different electrophiles: 2-bromo-4'-nitroacetophenone, 2-amino-4-chloro-methylthiazole hydrochloride, methyl iodide, 1,3-diiodopropane and 1,3-dibromopropane are reported. The synthesis yield by microwave dielectric heating is improved and reaction time shortened compared to conventional heating. The structure of obtained molecules were analyzed and determined by 1D and 2D NMR spectroscopy methods, IR spectroscopy and mass spectrometry. The highest antibacterial activity against two Gram-positive and two Gram-negative bacteria strains has been found for 1-[2-(4-nitrophenyl)-2-oxoethyl]pyridinium bromide (2).

Creative Commons License This work is licensed under a Creative Commons Attribution 4.0 International License.

Ključne riječi
microwave synthesis; pyridine derivatives; antibacterial activity; NMR; quaternization

Hrčak ID: 185680

URI
https://hrcak.srce.hr/185680

Posjeta: 846 *