Izvorni znanstveni članak

https://doi.org/10.1515/acph-2017-0031

Spectrophotometric method for simultaneous determination of valsartan and substances from the group of statins in binary mixtures

MARIUSZ STOLARCZYK ; Department of Inorganic and Analytical Chemistry, Jagiellonian University Medical College, Faculty of Pharmacy, 30-688 Kraków, Poland
ANNA APOLA ; Department of Inorganic and Analytical Chemistry, Jagiellonian University Medical College, Faculty of Pharmacy, 30-688 Kraków, Poland
ANNA MAŚLANKA ; Department of Inorganic and Analytical Chemistry, Jagiellonian University Medical College, Faculty of Pharmacy, 30-688 Kraków, Poland
ANNA KWIECIEŃ ; Department of Inorganic and Analytical Chemistry, Jagiellonian University Medical College, Faculty of Pharmacy, 30-688 Kraków, Poland
WŁODZIMIERZ OPOKA ; Department of Inorganic and Analytical Chemistry, Jagiellonian University Medical College, Faculty of Pharmacy, 30-688 Kraków, Poland

Sažetak

Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin – D1, D2 and D3, for valsartan and pravastatin – D1 and D3, for valsartan and atorvastatin – D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28–32.48 g mL–1 for valsartan, 8.16–28.56 g mL–1 for fluvastatin, 14.40–39.90 g mL–1 for atorvastatin and 9.60–48.00 g mL–1 for pravastatin. Determination coefficients were in the range of 0.989–0.999 depending on the analyte and the order of derivative. The precision of the method was high with RSD from 0.1 to 2.5 % and recovery of individual components was within the range of 100  5 %. The developed method was successfully applied to the determination of valsartan combined with fluvastatin, atorvastatin and pravastatin in laboratory prepared mixtures and in pharmaceutical preparations.

Ključne riječi

valsartan; atorvastatin; fluvastatin; pravastatin; derivative spectrophotometry

Hrčak ID:

186325

URI

https://hrcak.srce.hr/186325

Datum izdavanja:

31.12.2017.

Posjeta: 1.667 *