Izvorni znanstveni članak
https://doi.org/10.7906/indecs.15.3.4
Automated interpretable computational biology in the clinic: a framework to predict disease severity and stratify patients from clinical data
Soumya Banerjee
; University of Oxford, Oxford, United Kingdom
Sažetak
We outline an automated computational and machine learning framework that predicts disease severity and stratifies patients. We apply our framework to available clinical data. Our algorithm automatically generates insights and predicts disease severity with minimal operator intervention. The computational framework presented here can be used to stratify patients, predict disease severity and propose novel biomarkers for disease. Insights from machine learning algorithms coupled with clinical data may help guide therapy, personalize treatment and help clinicians understand the change in disease over time. Computational techniques like these can be used in translational medicine in close collaboration with clinicians and healthcare providers. Our models are also interpretable, allowing clinicians with minimal machine learning experience to engage in model building. This work is a step towards automated machine learning in the clinic.
Ključne riječi
disease severity prediction; machine learning; computational technique; big data
Hrčak ID:
188373
URI
Datum izdavanja:
24.10.2017.
Posjeta: 1.032 *