Croatica Chemica Acta, Vol. 57 No. 2, 1984.
Izvorni znanstveni članak
The Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of N-[(3-Substituted)aminocarbonyl]propanoyl-L-prolines
Vitomir Šunjić
; Department of Organic Chemistry and Biochemistry »Ruder Boskovic« Institute, 41001 Zagreb, Yugoslavia
Šumski Šimaga
; Department of Organic Chemistry and Biochemistry »Ruder Boskovic« Institute, 41001 Zagreb, Yugoslavia
Ljubinka Vitale
; Department of Organic Chemistry and Biochemistry »Ruder Boskovic« Institute, 41001 Zagreb, Yugoslavia
Sažetak
Preparations of N-[3-(hetero)aryl-aminocarbonyl]propanoyl-
L-proline derivatives 12, 13, 22 and 23 are described. A novel
approach consists of fusing (80-100 °C) N-(hetero)aryl-succinimides
(7, 8, 20, 21) with unprotected L-proline and imidazole in the presence
of dimethylformamide. In vitro tests for angiotensin converting
enzyme (ACE) inhibition showed that all N-(arylaminocarbonyl)-
propanoyl-L-prolines (12, 13, 22 and 23) exhibit lower
activity than captopril (1), their IC50's ranging from 2.5 X 10-4 to
3.3 X 10-3 M.
Ključne riječi
Hrčak ID:
194162
URI
Datum izdavanja:
6.4.1984.
Posjeta: 913 *