Croatica Chemica Acta, Vol. 53 No. 2, 1980.
Izlaganje sa skupa
Behavior of Proteins at Interfaces
A. G. Walton
; Department of Macromolecular Science Case Western Reserve University, Cleveland, Ohio 44106, U.S.A.
M. E. Soderquist
; Department of Macromolecular Science Case Western Reserve University, Cleveland, Ohio 44106, U.S.A.
Sažetak
The adsorption and conformational changes of three plasma
proteins, (bovine) serum albumin, .y-globulin and fibrinogen, on
several (bio)polymer surfaces are reported. A theory is developed
which invokes reversible adsorption of the proteins in the initial
stages and a time dependent conformational change of adsorbed
protein leading to essentially irreversible long-term adsorption.
In each case experimental evidence indicates that there .is a time-
dependent decrease in structural order. It is postulated that the
protein unfolds to optimize surface bonding, thus inducing the
c;hemistry of the protein/water interface by bonding at the protein/
/polymer interface. Cell binding studies support the concept that
the plasma proteins unfold to optimize the polymer/protein interaction.
Ključne riječi
Hrčak ID:
194597
URI
Datum izdavanja:
5.11.1980.
Posjeta: 566 *