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The Action of Hydrazines upon 'Thiazolidine-4-carboxylic Acids I. Preparation of D-Penicillamine from D-Benzylpenilloic Acid

J. J. Herak ; Research Department, PHva Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
M. Kovačević ; Research Department, PHva Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
B. Gašpert ; Research Department, PHva Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia


Puni tekst: engleski pdf 3.568 Kb

str. 141-148

preuzimanja: 508

citiraj


Sažetak

In the reaction of phenylhydrazine with n-benzylpenilloic acids
(Ia or Ila) n-penicillamine was obtained in high yield and purity.
The lack of reactivity of N-acyl derivatives (Ib or Ub) with phenylhydrazine
indicated that the above reaction proceeded through
the open chain imine tautomer of Ia or Ila (IV). The epim~risation
of n-benzylpenilloic acid (Ia and Ha) in aprotic solvents was studied
by using PMR spectroscopy.

Ključne riječi

Hrčak ID:

196428

URI

https://hrcak.srce.hr/196428

Datum izdavanja:

25.3.1977.

Posjeta: 794 *