hrcak mascot   Srce   HID

Izvorni znanstveni članak

Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus

U. Valcavi ; Istituto Biochimico Italiano, 20139 Milano, Italia
M. Japelj ; KRKA, Pharmaceutical and Chemical Works, 68000 Novo Mesto, Slovenia, Yugoslavia
S. Tedeschi ; Istituto Biochimico Italiano, 20139 Milano, Italia

Puni tekst: engleski, pdf (7 MB) str. 611-617 preuzimanja: 111* citiraj
APA 6th Edition
Valcavi, U., Japelj, M. i Tedeschi, S. (1973). Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus. Croatica Chemica Acta, 45 (4), 611-617. Preuzeto s https://hrcak.srce.hr/197011
MLA 8th Edition
Valcavi, U., et al. "Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus." Croatica Chemica Acta, vol. 45, br. 4, 1973, str. 611-617. https://hrcak.srce.hr/197011. Citirano 21.04.2021.
Chicago 17th Edition
Valcavi, U., M. Japelj i S. Tedeschi. "Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus." Croatica Chemica Acta 45, br. 4 (1973): 611-617. https://hrcak.srce.hr/197011
Harvard
Valcavi, U., Japelj, M., i Tedeschi, S. (1973). 'Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus', Croatica Chemica Acta, 45(4), str. 611-617. Preuzeto s: https://hrcak.srce.hr/197011 (Datum pristupa: 21.04.2021.)
Vancouver
Valcavi U, Japelj M, Tedeschi S. Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus. Croatica Chemica Acta [Internet]. 1973 [pristupljeno 21.04.2021.];45(4):611-617. Dostupno na: https://hrcak.srce.hr/197011
IEEE
U. Valcavi, M. Japelj i S. Tedeschi, "Mechanism of Hydroxylation of Steroids. Hydroxylation of 16a-Methyl-4-pregnene-21-ol-3,20- dione Acetate with Mucor Griseo-Cyanus", Croatica Chemica Acta, vol.45, br. 4, str. 611-617, 1973. [Online]. Dostupno na: https://hrcak.srce.hr/197011. [Citirano: 21.04.2021.]

Sažetak
Mucor griseo-cyanus, which introduces an hydroxyl group in
the 14-position of several steroids, converts 16a-methyl-4-pregnene-
21-ol-3,20-dione acetate (I) into a monohydrox:yderiva1Jive for which
the structure 16a-methyl-4-pregnene-7a,21-diol-3,20-dione (III) has
been determined. 16a-Methyl-4-pregnene-21-ol-3,20-dione acetate (I) and 16a- methyl-4-pregnene-7a,21-diol-3,20-dione (III) are transformed by Mucor griseo-cyanus, with a long time of incubation, into a dihydroxyderivative for which the structure 16a-methyl-4-pregnene- 7a,12~,21-triol-3,20-dione triacetate (VI) has been determined. The, 16a-methyl group in compound I inhibits the 14n-hydroxylase of Mucor griseo-cyanus by steric hindrance.

Hrčak ID: 197011

URI
https://hrcak.srce.hr/197011

Posjeta: 153 *