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Electrochemical Reduction of Intermediates in the Vitamin B6 Production. I. Reduction of 2-Methyl-3-nitro-4-methoxymethyl- 5-cyano-6-chloropyridine

M. Laćan ; Faculty of Technology, University of Zagreb
I. Tabaković ; High Military Technical School, Zagreb
J. Hranilović ; PLIVA, Pharmaceutical and Chemical Works, Zagreb
N. Bujas ; Technical Faculty, Banja Luka
Z. Stunić ; Institute of Food Science and Technology, Zagreb

Puni tekst: engleski pdf 7.408 Kb

str. 229-235

preuzimanja: 174



2-Methy 1-3-ni tro-4-metoxymethy 1-5-cyano-6-chloropyridine (I)
was reduced on a mercury-pool cathode in an electrolytic cell fitted
with a diaphragm. The catholyte consisted of a mixture of acetiC
acid and hydrochloric acid and the anolyte was dilute hydrochloric
acid. At a potential of - 0.5 V vs. SCE. compound I was reduced
to 2-methy 1-3-amino-4-methoxymethy 1-5-cyano-6-chloropyridine
(II). Compound II was reduced at a potential of -1.1 V vs. SCE.
to give 2,4-dimethyl-3-amino-5-cyanopyridine (Ill). Compound III
was reduced at constant current density to 2,4-dimethyl-3-amino-
5-aminomethylpyridine (IV). The influence of several factors (depolarizer concentration, electrolyte concentration and temperature) on yield of products was examined in each step. Polarograms were recorded with compounds I, II and III, and the character of limiting currents was assessed using the usual criteria.

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