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https://doi.org/10.2478/acph-2018-0039

Chloroquine urea derivatives: synthesis and antitumor activity in vitro

KRISTINA PAVIĆ ; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, HR-10 000 Zagreb, Croatia
ZRINKA RAJIĆ ; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, HR-10 000 Zagreb, Croatia
ZVONIMIR MLINARIĆ   ORCID icon orcid.org/0000-0003-2571-2461 ; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, HR-10 000 Zagreb, Croatia
LIDIJA UZELAC   ORCID icon orcid.org/0000-0002-3076-7064 ; Rudjer Bošković Institute, Division of Molecular Medicine, Laboratory of Experimental Therapy, HR-10 000 Zagreb, Croatia
MARIJETA KRALJ ; Rudjer Bošković Institute, Division of Molecular Medicine, Laboratory of Experimental Therapy, HR-10 000 Zagreb, Croatia
BRANKA ZORC   ORCID icon orcid.org/0000-0003-4355-8816 ; University of Zagreb Faculty of Pharmacy and Biochemistry, Department of Medicinal Chemistry, HR-10 000 Zagreb, Croatia

Puni tekst: engleski, pdf (413 KB) str. 471-483 preuzimanja: 92* citiraj
APA 6th Edition
PAVIĆ, K., RAJIĆ, Z., MLINARIĆ, Z., UZELAC, L., KRALJ, M. i ZORC, B. (2018). Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta Pharmaceutica, 68 (4), 471-483. https://doi.org/10.2478/acph-2018-0039
MLA 8th Edition
PAVIĆ, KRISTINA, et al. "Chloroquine urea derivatives: synthesis and antitumor activity in vitro." Acta Pharmaceutica, vol. 68, br. 4, 2018, str. 471-483. https://doi.org/10.2478/acph-2018-0039. Citirano 17.11.2019.
Chicago 17th Edition
PAVIĆ, KRISTINA, ZRINKA RAJIĆ, ZVONIMIR MLINARIĆ, LIDIJA UZELAC, MARIJETA KRALJ i BRANKA ZORC. "Chloroquine urea derivatives: synthesis and antitumor activity in vitro." Acta Pharmaceutica 68, br. 4 (2018): 471-483. https://doi.org/10.2478/acph-2018-0039
Harvard
PAVIĆ, K., et al. (2018). 'Chloroquine urea derivatives: synthesis and antitumor activity in vitro', Acta Pharmaceutica, 68(4), str. 471-483. https://doi.org/10.2478/acph-2018-0039
Vancouver
PAVIĆ K, RAJIĆ Z, MLINARIĆ Z, UZELAC L, KRALJ M, ZORC B. Chloroquine urea derivatives: synthesis and antitumor activity in vitro. Acta Pharm. [Internet]. 2018 [pristupljeno 17.11.2019.];68(4):471-483. https://doi.org/10.2478/acph-2018-0039
IEEE
K. PAVIĆ, Z. RAJIĆ, Z. MLINARIĆ, L. UZELAC, M. KRALJ i B. ZORC, "Chloroquine urea derivatives: synthesis and antitumor activity in vitro", Acta Pharmaceutica, vol.68, br. 4, str. 471-483, 2018. [Online]. https://doi.org/10.2478/acph-2018-0039

Sažetak
In the current paper, we describe design, synthesis and antiproliferative screening of novel chloroquine derivatives with a quinoline core linked to a hydroxy or halogen amine through a flexible aminobutyl chain and urea spacer. Synthetic pathway leading to chloroquine urea derivatives 4-10 includes two crucial steps: i) synthesis of chloroquine benzotriazolide 3 and ii) formation of the urea derivatives through the reaction of compound 3 with the corresponding amine. Testing of antiproliferative activity against four human cancer cell lines revealed that chloroquine urea derivatives 9 and 10 with aromatic moieties show activity in micromolar concentrations. Therefore, these molecules represent interesting lead compounds that might provide insight into the design of new anticancer agents.

Ključne riječi
chloroquine; hydroxychloroquine; urea; antitumor activity in vitro

Hrčak ID: 203273

URI
https://hrcak.srce.hr/203273

Posjeta: 200 *