Croatica Chemica Acta, Vol. 33 No. 3, 1961.
Izvorni znanstveni članak
Synthesis of 2-iso-Propyl-3-methyl-huten-(3)-ol-(l)
K Šestanj
; Research Department »Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
Sažetak
The title compound was synthesized in the following way:
Reforinatsky condensation ·of ethyl a -bromo-iso-valerate with
acetone and zinc to ethyl 3-hydroxy-2-iso-propyl-3-methyl-butyrate
(1), dehydration to the mixture of ethyl 2-iso-propyl-3-methylbuten-(
3)-oate (II) and 2-iso-propyl-3-methyl-buten-(2)-oate (IV),
and lithium aluminum hydride reduction to 2-iso-propyl-3-methylbuten-(
3)-ol-(1) (VI). The mixture of esters was hydrolysed to
2-iso-propyl-3-methyl-buten-(3)-oic acid (III) which gave on
reduction with lithium aluminum hydride the same alcohol VI.
Proof of the structure of the acid III was accomplished by means
of chemical and physical methods.
Ključne riječi
Hrčak ID:
208433
URI
Datum izdavanja:
15.1.1962.
Posjeta: 777 *