Kratko priopćenje

https://doi.org/10.2478/acph-2019-0027

Secondary metabolites from resins of Aloe vera and Commiphora mukul mitigate lipid peroxidation

NAJEEB UR REHMAN ; Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
SAMIA AHMED AL-RIYAMI ; Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
HIDAYAT HUSSAIN ; Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
AMJAD ALI ; Natural & Medical Sciences Research Center, University of Nizwa, Nizwa, Sultanate of Oman
ALI ABDUL LATIF KHAN ; UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman
AHMED AL-HARRASI ; UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, P.O Box 33, Postal Code 616, Birkat Al Mauz, Nizwa, Sultanate of Oman

Sažetak

Oxidative stress is often considered detrimental for cellular processes and damaging for the lipid bi-layer. Counteracting such stresses with the aid of nature-based chemical constituents can be an ideal therapeutic approach. The current study aimed to investigate the chemical constituents of resins derived from the well-known Aloe vera and less known Commiphora mukul trees and their effect in mitigating the lipid peroxidation (LPO) process. The bio-guided isolation of bioactive fractions from both resins afforded 20 chemical constituents (17 from A. vera and 3 from C. mukul). These compounds belonged to anthraquinones, anthraquinone glycosides, quinones, coumarins, polypodane-type terpenoids and benzene derivatives. Major chemical constituents of the resins of A. vera and C. mukul were from the classes of quinones and terpenoids. Feroxidin (4, from A. vera) showed slightly higher inhibition (IC50 = 201.7 ± 0.9 µmol L–1) than myrrhanone C (18, from C. mukul: IC50 = 210.7 ± 0.0 µmol L–1) and methyl 3-(4-hydroxyphenyl) propionate from A. vera (13, IC50 = 232.9 ± 0.2 µmol L–1) compared to the other compounds. Structure-activity relationship showed that the existence of hydroxyl, methoxy and ether groups might play a major role in countering oxidative stress. To the best of our knowledge, anti-LPO activities of compounds 1–4, 14, 18 and 20 are reported for the first time. Such chemical constituents with high anti-lipid peroxidation activity could be helpful in synthesizing candidate drugs.

Ključne riječi

Aloe vera; Commiphora mukul; anti-LPO; feroxidin; myrrhanone C

Hrčak ID:

216132

URI

https://hrcak.srce.hr/216132

Datum izdavanja:

30.9.2019.

Posjeta: 1.719 *