Ostalo
Penicillin-induced cutaneous necrotizing eosinophilic vasculitis with cryofibrinogenemia
Branislav Lekić
Mirjana Gajić-Veljić
Branka Bonači-Nikolić
Miloš Nikolić
; Department of DermatovenereologyFaculty of Medicine, University of BelgradePasterova 211000 BelgradeSerbia
Sažetak
Cutaneous necrotizing eosinophilic vasculitis (CNEV) is a rare type of vasculitis. Eosinophilic vasculitis is a necrotizing vasculitis with eosinophilic vascular infiltration, in which eosinophils mediate vascular damage in the disease process. We present a case of an 18-year-old girl who developed palpable purpura and hemorrhagic bullae over the lower extremities associated with itching, 7 days after the commencement of penicillin therapy. Plasma cryofibrinogen was positive. Histopathology showed an infiltration of eosinophils within and around the vessel walls and a complete absence of nuclear dust and neutrophils. Oral prednisone at 1 mg/kg induced remission in 2 weeks; the prednisone dose was tapered and discontinued after 2.5 months. There was no evidence of recurrence after 37 months of follow-up. Our patient represents a rare case of drug/penicillin-induced CNEV associated with cryofibrinogenemia, without systemic organ involvement.
, and histopathological features of the lesion. Moreover, the possible complications of surgical approaches, namely healing defects, failure of skin grafts, and wound infection, should be considered. In this review we discuss the management of BCC localized on the face and scalp, according to the currently available treatment options.
Ključne riječi
Hrčak ID:
219586
URI
Datum izdavanja:
25.4.2019.
Posjeta: 858 *