Izvorni znanstveni članak

https://doi.org/10.20471/acc.2019.58.01.02

Sonoelastographic Features of High-Risk Breast Lesions and Ductal Carcinoma in situ – a Pilot Study

Maja Crnogorac ; Department of Diagnostic and Interventional Radiology, Dubrava University Hospital, Zagreb, Croatia
Gordana Ivanac ; Department of Diagnostic and Interventional Radiology, Dubrava University Hospital, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia
Čedna Tomasović-Lončarić ; University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Pathology, Dubrava University Hospital, Zagreb, Croatia
Rado Žic ; University of Zagreb, School of Medicine, Zagreb, Croatia; Department of Plastic and Reconstructive Surgery, Dubrava University Hospital, Zagreb, Croatia
Tomislav Kelava ; Department of Physiology and Immunology, University of Zagreb, School of Medicine, Zagreb, Croatia
Boris Brkljačić ; Department of Diagnostic and Interventional Radiology, Dubrava University Hospital, Zagreb, Croatia; University of Zagreb, School of Medicine, Zagreb, Croatia

Sažetak

The aim of this study was to evaluate the quantitative sonoelastographic values
recorded on shear-wave sonoelastography (SWE) of high-risk breast lesions and ductal carcinoma in
situ (DCIS). We retrospectively analyzed histopathologic and SWE data (quantitative maximum,
minimum and mean stiffness, lesion-to-fat ratio (E-ratio), lesion size) of 228 women referred to our
Department for core needle breast biopsy during a four-year period. Among 230 lesions, histopathologic
findings showed 34 high-risk breast lesions and 29 DCIS, which were compared with 167 ductal
invasive carcinomas. High-risk lesions had lower values of all sonoelastographic features than ductal
in situ and invasive carcinoma, however, only E-ratio showed a statistically significant difference in
comparison to DCIS (3.7 vs. 6, p<0.001). All sonoelastographic features showed significant difference
between in situ and invasive carcinoma. There was a significant correlation between lesion size and
stiffness (r=0.36; p<0.001). Stiffness measured by SWE is an effective predictor of the histopathologic
severity of sonographically detectable breast lesions. Elasticity values of high-risk lesions are
significantly lower than those of malignant lesions. Furthermore, we showed that along with the sonographic
appearance, which in most cases shows typical microcalcifications, DCIS had significantly
different elasticity parameters than invasive carcinoma.

Ključne riječi

Breast neoplasms – diagnostic imaging; Breast neoplasms – classification; Elastic modulus; Ultrasonography, mammary; Elasticity imaging techniques; Sensitivity and specificity; Carcinoma, intraductal; Shear-wave elastography (SWE)

Hrčak ID:

220487

URI

https://hrcak.srce.hr/220487

Datum izdavanja:

1.3.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.528 *