Acta Pharmaceutica, Vol. 70 No. 2, 2020.
Kratko priopćenje
https://doi.org/10.2478/acph-2020-0019
Potential antidiabetic and antioxidant activities of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. Leaves
SAMUEL O. ONOJA
; Department of Veterinary Physiology and Pharmacology, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Nigeria
CHARLES O. NNADI
; Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria Nsukka, 410001 Enugu State, Nigeria
SAMUEL C. UDEM
; Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria Nsukka, 410001 Enugu State, Nigeria
ARUH O. ANAGA
; Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, 410001 Enugu State, Nigeria
Sažetak
Heliangolide is a naturally occurring sesquiterpene lactone and its derivatives are biologically active compounds present in most medicinal plants. This study evaluated the antioxidant and antidiabetic properties of a heliangolide sesquiterpene lactone isolated from Helianthus annuus L. leaves. The heliangolide sesquiterpene lactone was isolated through combination of solvent-solvent partitioning, column chromatography, thin layer chromatography and high performance-liquid chromatography techniques. The antioxidant activity of the compound was evaluated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide radical scavenging assays while the antidiabetic effects were investigated in alloxan-induced diabetic rats. The heliangolide derivative at 954.2 µmol L–1 showed 23.7 % DPPH and 26 % nitric oxide radical inhibitions compared with 96.6 and 50.9 %, resp., displayed by the controls (2,271.2 µmol L–1). It also reduced the fasting blood glucose (FBG) levels in a time-dependent manner. The highest activity was recorded within 6 h post-treatment at 0.2 mmol kg–1 bm. The heliangolide derivative exhibited significant (p < 0.05) antioxidant and antidiabetic properties and provides basis for further development of constituents of Helianthus annuus leaves for the management of such diseases.
Ključne riječi
Helianthus annuus; heliangolide derivative; antidiabetic; antioxidant
Hrčak ID:
221294
URI
Datum izdavanja:
30.6.2020.
Posjeta: 1.863 *