Izvorni znanstveni članak

https://doi.org/10.24099/vet.arhiv.0249

Evaluation of treatment with bone marrow derived monocytes of minipigs in muscle fibres after exposure to Bisphenol-A

Carlos Abellán ; Departamento Farmacología, Toxicología, y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Córdoba, Campus de Rabanales Carretera Madrid-Cádiz s/n, Córdoba, Spain
Ana Molina orcid.org/0000-0002-2645-7303 ; Departamento Farmacología, Toxicología, y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Córdoba, Campus de Rabanales Carretera Madrid-Cádiz s/n, Córdoba, Spain
Cristina Bellido ; Departamento Farmacología, Toxicología, y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Córdoba, Campus de Rabanales Carretera Madrid-Cádiz s/n, Córdoba, Spain
Alfonso Blanco ; Departamento Anatomía y Anatomía Patológica Comparadas, Facultad de Veterinaria, Universidad de Córdoba, Campus de Rabanales Carretera Madrid-Cádiz s/n, Córdoba, Spain
Rosario Moyano ; Departamento Farmacología, Toxicología, y Medicina Legal y Forense, Facultad de Veterinaria, Universidad de Córdoba, Campus de Rabanales Carretera Madrid-Cádiz s/n, Córdoba, Spain

Sažetak

Bisphenol-A (BPA) has been described as an endocrine disruptor that impairs human and animal health. As BPA is present in food and drink, due to leaching from polycarbonate containers or aluminum cans, humans are constantly exposed to it. Due to the importance for public health of unconscious exposure to BPA, we conducted a study of its rapid action on muscle tissue and its possible treatment with bone marrow monocytes. For this purpose, 16 minipigs were randomly distributed (n = 4) to one of the following experimental groups: the control group treated with BPA (for 4 months), the BPA-withdrawal group (treated for 2 months with BPA and two months without), and the bone marrow monocytes (MN) group (treated for 2 months with BPA, after which it was withdrawn and MN treatment began lasting 2 months). At the end of the treatments, biopsy of the longissimus lumbaris (LL) was carried out. The samples were analysed by optical and electron microscopy. In our study, it was observed that after continuous exposure to BPA some alterations appeared both in the muscle fibres and in the collagen fibres of their sheaths. The group from which BPA was withdrawn for two months exhibited a reversible degenerative action, with a partial recovery of both the muscle and the collagen fibres. In the last study group, we evaluated the action of the bone marrow monocytes on the modified muscle tissue, and observed that they presented a notable recovery action since practically all the muscle and collagen fibre alterations which had appeared were reversed.

Ključne riječi

Bisphenol A; minipig; muscle; bone marrow monocytes

Hrčak ID:

222717

URI

https://hrcak.srce.hr/222717

Datum izdavanja:

12.7.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.318 *