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https://doi.org/10.20471/acc.2019.58.02.06

Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study

Maja Baretić   ORCID icon orcid.org/0000-0002-7242-8407 ; Division of Endocrinology, Department of Internal Medicine, Zagreb University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Vesna Kušec ; Clinical Institute of Laboratory Diagnosis, Zagreb University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Valentina Uroić   ORCID icon orcid.org/0000-0002-2579-560X ; Department of Nutrition and Dietetics, Zagreb University Hospital Centre, Zagreb, Croatia
Ivana Pavlić-Renar ; Division of Endocrinology, Department of Internal Medicine, Zagreb University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia
Velimir Altabas ; Department of Endocrinology, Diabetes and Metabolic Diseases, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (410 KB) str. 240-247 preuzimanja: 95* citiraj
APA 6th Edition
Baretić, M., Kušec, V., Uroić, V., Pavlić-Renar, I. i Altabas, V. (2019). Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study. Acta clinica Croatica, 58 (2.), 240-247. https://doi.org/10.20471/acc.2019.58.02.06
MLA 8th Edition
Baretić, Maja, et al. "Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study." Acta clinica Croatica, vol. 58, br. 2., 2019, str. 240-247. https://doi.org/10.20471/acc.2019.58.02.06. Citirano 30.10.2020.
Chicago 17th Edition
Baretić, Maja, Vesna Kušec, Valentina Uroić, Ivana Pavlić-Renar i Velimir Altabas. "Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study." Acta clinica Croatica 58, br. 2. (2019): 240-247. https://doi.org/10.20471/acc.2019.58.02.06
Harvard
Baretić, M., et al. (2019). 'Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study', Acta clinica Croatica, 58(2.), str. 240-247. https://doi.org/10.20471/acc.2019.58.02.06
Vancouver
Baretić M, Kušec V, Uroić V, Pavlić-Renar I, Altabas V. Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study. Acta clinica Croatica [Internet]. 2019 [pristupljeno 30.10.2020.];58(2.):240-247. https://doi.org/10.20471/acc.2019.58.02.06
IEEE
M. Baretić, V. Kušec, V. Uroić, I. Pavlić-Renar i V. Altabas, "Glucagon-Like Peptide-1 Affects Taste Perception Differently in Women: a Randomized, Placebo-Controlled Crossover Study", Acta clinica Croatica, vol.58, br. 2., str. 240-247, 2019. [Online]. https://doi.org/10.20471/acc.2019.58.02.06

Sažetak
Gastrointestinal tract is an important connector between food intake and body weight, it senses basic tastes in a similar manner as the tongue. The aim of the study was to find out how gut hormone glucagon-like peptide-1 (GLP-1) influences taste preference. Fourteen healthy participants (six male and eight female) were included in this double-blind, placebo-controlled crossover study. After overnight fast and salty fluid (oral sodium load), participants were randomized to receive placebo (500 mL of 0.9% saline) or GLP-1 infusion (1.5 pmol/kg/min) over a 3-hour period. At the end of infusion, participants chose food preferences from illustrations of food types representing
5 tastes. After 7 days, the protocol was repeated, this time those that had received placebo first got GLP-1 infusion, and those having received GLP-1 first got placebo. Change of taste preference after GLP-1 infusion but not after placebo was reported as response, and non-response was reported in case of taste persistence. A statistically significant difference in response type was found between genders, with women being more likely to change their taste preference after GLP-1 than men. The change of taste upon GLP-1 infusion observed in women might be ascribed to estrogen weight-lowering effects accomplished by receptor-mediated delivery.

Ključne riječi
Glucagon-like peptide 1; Taste; Food preferences; Cross-over studies; Double-blind method

Hrčak ID: 224352

URI
https://hrcak.srce.hr/224352

[hrvatski]

Posjeta: 280 *