Kratko priopćenje

https://doi.org/10.2478/v10007-008-0010-7

N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

JULIJA MATIJEVIĆ-SOSA ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
ITA SAMARŽIJA ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
LORENA HONOVIĆ ; Clinical Laboratory, General Hospital Pula, Pula, Croatia
BLAŽENKA JURIŠIĆ ; Agency for Medicinal Products and Medicinal Devices of Republic of Croatia, Zagreb

Sažetak

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible

Ključne riječi

N-phthaloyl-glycine-hydroxamic acid; iron chelators; iron overload

Hrčak ID:

22674

URI

https://hrcak.srce.hr/22674

Datum izdavanja:

1.6.2008.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.550 *