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Pregledni rad
https://doi.org/10.2478/acph-2020-0031

2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses

GEORGETA SERBAN   ORCID icon orcid.org/0000-0002-2926-0995 ; Pharmaceutical Chemistry Department, Faculty of Medicine and Pharmacy, University of Oradea, 410028 Oradea, Romania

Puni tekst: engleski, pdf (715 KB) str. 259-290 preuzimanja: 151* citiraj
APA 6th Edition
SERBAN, G. (2020). 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses. Acta Pharmaceutica, 70 (3), 259-290. https://doi.org/10.2478/acph-2020-0031
MLA 8th Edition
SERBAN, GEORGETA. "2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses." Acta Pharmaceutica, vol. 70, br. 3, 2020, str. 259-290. https://doi.org/10.2478/acph-2020-0031. Citirano 29.09.2020.
Chicago 17th Edition
SERBAN, GEORGETA. "2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses." Acta Pharmaceutica 70, br. 3 (2020): 259-290. https://doi.org/10.2478/acph-2020-0031
Harvard
SERBAN, G. (2020). '2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses', Acta Pharmaceutica, 70(3), str. 259-290. https://doi.org/10.2478/acph-2020-0031
Vancouver
SERBAN G. 2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses. Acta Pharm. [Internet]. 2020 [pristupljeno 29.09.2020.];70(3):259-290. https://doi.org/10.2478/acph-2020-0031
IEEE
G. SERBAN, "2-Amino-1,3,4-thiadiazoles as prospective agents in trypanosomiasis and other parasitoses", Acta Pharmaceutica, vol.70, br. 3, str. 259-290, 2020. [Online]. https://doi.org/10.2478/acph-2020-0031

Sažetak
Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scientific papers report the antiparasitic potential of 2-amino-1,3,4-thiadiazoles. This review presents synthetic 2-amino-1,3,4-thiadiazoles exhibiting antitrypanosomal, antimalarial and antitoxoplasmal activities. Although there are insufficient results to state the quality of 2-amino-1,3,4-thiadiazoles as a new class of antiparasitic agents, many reported derivatives can be considered as lead compounds for drug synthesis and a promise for the future treatment of parasitosis and provide a valid strategy for the development of potent antiparasitic drugs.

Ključne riječi
2-amino-1,3,4-thiadiazoles; antiparasitic activity; antitrypanosomal activity; antimalarial activity; antitoxoplasmal activity; inhibitory concentration

Hrčak ID: 227178

URI
https://hrcak.srce.hr/227178

Posjeta: 290 *