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Hh-Gli Signaling Pathway Functions and Its Therapeutic Potential in Cancer

Sonja Levanat ; Ruđer Bošković Institute, Zagreb, Croatia
Maja Čretnik ; Ruđer Bošković Institute, Zagreb, Croatia
Vesna Musani ; Ruđer Bošković Institute, Zagreb, Croatia

Puni tekst: engleski, pdf (102 KB) str. 1-5 preuzimanja: 946* citiraj
APA 6th Edition
Levanat, S., Čretnik, M. i Musani, V. (2008). Hh-Gli Signaling Pathway Functions and Its Therapeutic Potential in Cancer. Croatica Chemica Acta, 81 (1), 1-5. Preuzeto s https://hrcak.srce.hr/23356
MLA 8th Edition
Levanat, Sonja, et al. "Hh-Gli Signaling Pathway Functions and Its Therapeutic Potential in Cancer." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 1-5. https://hrcak.srce.hr/23356. Citirano 29.07.2021.
Chicago 17th Edition
Levanat, Sonja, Maja Čretnik i Vesna Musani. "Hh-Gli Signaling Pathway Functions and Its Therapeutic Potential in Cancer." Croatica Chemica Acta 81, br. 1 (2008): 1-5. https://hrcak.srce.hr/23356
Harvard
Levanat, S., Čretnik, M., i Musani, V. (2008). 'Hh-Gli Signaling Pathway Functions and Its Therapeutic Potential in Cancer', Croatica Chemica Acta, 81(1), str. 1-5. Preuzeto s: https://hrcak.srce.hr/23356 (Datum pristupa: 29.07.2021.)
Vancouver
Levanat S, Čretnik M, Musani V. Hh-Gli Signaling Pathway Functions and Its Therapeutic Potential in Cancer. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 29.07.2021.];81(1):1-5. Dostupno na: https://hrcak.srce.hr/23356
IEEE
S. Levanat, M. Čretnik i V. Musani, "Hh-Gli Signaling Pathway Functions and Its Therapeutic Potential in Cancer", Croatica Chemica Acta, vol.81, br. 1, str. 1-5, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/23356. [Citirano: 29.07.2021.]

Sažetak
Hh-Gli signaling pathway is one of the major and highly conserved pathways regulating embryogenesis and organ development. Its aberrant functioning is associated with malformations and cancer. Major proteins involved in the pathway are Hh, Ptch, Smo, and Gli1. Recent discoveries showed that the pathway is involved in many common and lethal tumors, such as breast, lung, prostate and digestive tract cancer. In these cases, tumor growth appears to require abnormal Hh stimulation from the surrounding cells, which causes a strong intracellular response of the pathway. Extensive involvement of the Hh-Gli pathway in tumor development has promoted it into an important target for cancer therapy, by discovery of a small molecule, cyclopamine, which was shown to block Smo. Successful tumor growth inhibition was accomplished both in cell cultures and on animal models. Current research includes analogous molecules, and alternative strategies of intervention on the other elements of the Hh-Gli pathway.

Ključne riječi
Hh-Gli signaling pathway; cancer; development; therapy

Hrčak ID: 23356

URI
https://hrcak.srce.hr/23356

Posjeta: 1.326 *