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Transduction of p27 to Induce Apoptosis in Tumor Cells

Mira Grdiša   ORCID icon orcid.org/0000-0001-5422-7188 ; Ruđer Bošković Institute, Zagreb, Croatia
Ana-Matea Mikecin ; Ruđer Bošković Institute, Zagreb, Croatia
Martina Grdiša ; Ruđer Bošković Institute, Zagreb, Croatia

Puni tekst: engleski, pdf (276 KB) str. 81-87 preuzimanja: 682* citiraj
APA 6th Edition
Grdiša, M., Mikecin, A. i Grdiša, M. (2008). Transduction of p27 to Induce Apoptosis in Tumor Cells. Croatica Chemica Acta, 81 (1), 81-87. Preuzeto s https://hrcak.srce.hr/23394
MLA 8th Edition
Grdiša, Mira, et al. "Transduction of p27 to Induce Apoptosis in Tumor Cells." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 81-87. https://hrcak.srce.hr/23394. Citirano 27.07.2021.
Chicago 17th Edition
Grdiša, Mira, Ana-Matea Mikecin i Martina Grdiša. "Transduction of p27 to Induce Apoptosis in Tumor Cells." Croatica Chemica Acta 81, br. 1 (2008): 81-87. https://hrcak.srce.hr/23394
Harvard
Grdiša, M., Mikecin, A., i Grdiša, M. (2008). 'Transduction of p27 to Induce Apoptosis in Tumor Cells', Croatica Chemica Acta, 81(1), str. 81-87. Preuzeto s: https://hrcak.srce.hr/23394 (Datum pristupa: 27.07.2021.)
Vancouver
Grdiša M, Mikecin A, Grdiša M. Transduction of p27 to Induce Apoptosis in Tumor Cells. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 27.07.2021.];81(1):81-87. Dostupno na: https://hrcak.srce.hr/23394
IEEE
M. Grdiša, A. Mikecin i M. Grdiša, "Transduction of p27 to Induce Apoptosis in Tumor Cells", Croatica Chemica Acta, vol.81, br. 1, str. 81-87, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/23394. [Citirano: 27.07.2021.]

Sažetak
Transduction is a biochemical technique for the introduction of full-length proteins into the cells. It has the potential to be used in the development of a new therapeutic strategy for cancer therapy. Different forms of p27 (TAT-p27, TAT-Mp27, TAT-p23) were transduced into tumor cell lines, lymphocytes and B-CLL cells, and their influence on proliferation and apoptosis was investigated. The metabolism of transduced proteins differed between the cell types. TAT-p27 protein is metabolized faster than the mutated form. Furthermore, the half-life of TAT-p27 depended on the type of cells. All forms of TAT-p27 fusion protein moderately decreased the proliferation of different types of the cells and induced apoptosis. The cells from some B-CLL patients were sensitive to TAT fusion proteins, and the sensitivity was increased with the addition of Fluda. This study provides valuable results for further development of TAT technology as the potential tool for a specially targeted therapy of tumors.

Ključne riječi
apoptosis; cell lines; B-CLL; p27

Hrčak ID: 23394

URI
https://hrcak.srce.hr/23394

Posjeta: 977 *