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Reduction in Peripheral Blood Leukocyte Heat Shock Proteins 27 and 70 Expression in Chronic Obstructive Pulmonary Disease

Lada Rumora   ORCID icon orcid.org/0000-0002-5302-3770 ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Lara Milevoj   ORCID icon orcid.org/0000-0003-0360-9148 ; University Hospital of Traumatology, Zagreb, Croatia
Sanja Popović-Grle ; School of Medicine, University of Zagreb, Zagreb, Croatia
Karmela Barišić   ORCID icon orcid.org/0000-0001-9666-5514 ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Tihana Žanić Grubišić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Ivana Čepelak ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (151 KB) str. 73-80 preuzimanja: 455* citiraj
APA 6th Edition
Rumora, L., Milevoj, L., Popović-Grle, S., Barišić, K., Žanić Grubišić, T. i Čepelak, I. (2008). Reduction in Peripheral Blood Leukocyte Heat Shock Proteins 27 and 70 Expression in Chronic Obstructive Pulmonary Disease. Croatica Chemica Acta, 81 (1), 73-80. Preuzeto s https://hrcak.srce.hr/23395
MLA 8th Edition
Rumora, Lada, et al. "Reduction in Peripheral Blood Leukocyte Heat Shock Proteins 27 and 70 Expression in Chronic Obstructive Pulmonary Disease." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 73-80. https://hrcak.srce.hr/23395. Citirano 17.09.2019.
Chicago 17th Edition
Rumora, Lada, Lara Milevoj, Sanja Popović-Grle, Karmela Barišić, Tihana Žanić Grubišić i Ivana Čepelak. "Reduction in Peripheral Blood Leukocyte Heat Shock Proteins 27 and 70 Expression in Chronic Obstructive Pulmonary Disease." Croatica Chemica Acta 81, br. 1 (2008): 73-80. https://hrcak.srce.hr/23395
Harvard
Rumora, L., et al. (2008). 'Reduction in Peripheral Blood Leukocyte Heat Shock Proteins 27 and 70 Expression in Chronic Obstructive Pulmonary Disease', Croatica Chemica Acta, 81(1), str. 73-80. Preuzeto s: https://hrcak.srce.hr/23395 (Datum pristupa: 17.09.2019.)
Vancouver
Rumora L, Milevoj L, Popović-Grle S, Barišić K, Žanić Grubišić T, Čepelak I. Reduction in Peripheral Blood Leukocyte Heat Shock Proteins 27 and 70 Expression in Chronic Obstructive Pulmonary Disease. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 17.09.2019.];81(1):73-80. Dostupno na: https://hrcak.srce.hr/23395
IEEE
L. Rumora, L. Milevoj, S. Popović-Grle, K. Barišić, T. Žanić Grubišić i I. Čepelak, "Reduction in Peripheral Blood Leukocyte Heat Shock Proteins 27 and 70 Expression in Chronic Obstructive Pulmonary Disease", Croatica Chemica Acta, vol.81, br. 1, str. 73-80, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/23395. [Citirano: 17.09.2019.]

Sažetak
Chronic obstructive pulmonary disease (COPD) is characterized by chronic local and systemic inflammation, and increased oxidative stress. Changes in peripheral blood leukocyte counts or in the fractions of leukocyte subsets might be implicated in the development of this disease. In this study, increased monocyte fraction was observed in COPD non-smokers. In light COPD smokers, the fraction of neutrophils was significantly increased along with significantly decreased lymphocyte fraction and lung function parameters. Heat shock proteins (Hsps) could stimulate antioxidant defence of cells by decreasing intracellular levels of reactive oxygen particles (ROS) and by neutralizing toxic effects of oxidized proteins. This study showed that the expression of Hsps in leukocytes was influenced by health and smoking status. Hsp70 and Hsp27 were significantly decreased in COPD ex-smokers and healthy smokers, but the most striking suppression in Hsps expression was detected in COPD smokers. It is suggested that this decline in Hsps intracellular levels could be implicated in the pathogenesis of COPD.

Ključne riječi
COPD; oxidative stress; Hsp27; Hsp70; leukocytes

Hrčak ID: 23395

URI
https://hrcak.srce.hr/23395

Posjeta: 739 *