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TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease

Sanja Marević   ORCID icon orcid.org/0000-0003-4465-1457 ; Dr Fran Mihaljević University Hospital for Infectious Diseases, Zagreb, Croatia
József Petrik ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Nada Vrkić ; Sestre milosrdnice University Hospital, Zagreb, Croatia
Sanja Popović-Grle ; Jordanovac University Hospital for Lung Diseases, Zagreb, Croatia
Tihana Žanić-Grubišić ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
Ivana Čepelak ; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (179 KB) str. 211-217 preuzimanja: 683* citiraj
APA 6th Edition
Marević, S., Petrik, J., Vrkić, N., Popović-Grle, S., Žanić-Grubišić, T. i Čepelak, I. (2008). TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease. Croatica Chemica Acta, 81 (1), 211-217. Preuzeto s https://hrcak.srce.hr/23450
MLA 8th Edition
Marević, Sanja, et al. "TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease." Croatica Chemica Acta, vol. 81, br. 1, 2008, str. 211-217. https://hrcak.srce.hr/23450. Citirano 17.05.2021.
Chicago 17th Edition
Marević, Sanja, József Petrik, Nada Vrkić, Sanja Popović-Grle, Tihana Žanić-Grubišić i Ivana Čepelak. "TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease." Croatica Chemica Acta 81, br. 1 (2008): 211-217. https://hrcak.srce.hr/23450
Harvard
Marević, S., et al. (2008). 'TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease', Croatica Chemica Acta, 81(1), str. 211-217. Preuzeto s: https://hrcak.srce.hr/23450 (Datum pristupa: 17.05.2021.)
Vancouver
Marević S, Petrik J, Vrkić N, Popović-Grle S, Žanić-Grubišić T, Čepelak I. TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 17.05.2021.];81(1):211-217. Dostupno na: https://hrcak.srce.hr/23450
IEEE
S. Marević, J. Petrik, N. Vrkić, S. Popović-Grle, T. Žanić-Grubišić i I. Čepelak, "TNF-alpha, CXCL8, big ET-1 and hsCRP in Patients with Chronic Obstructive Pulmonary Disease", Croatica Chemica Acta, vol.81, br. 1, str. 211-217, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/23450. [Citirano: 17.05.2021.]

Sažetak
COPD (chronic obstructive pulmonary disease) is a chronic progressive inflammatory disease characterised by limitations in lung airflow that is not fully reversible. The concentrations and correlations of TNF-á, CXCL8, big ET-1 and hsCRP were investigated in healthy non-smokers, healthy smokers and patients with COPD in order to study their possible role in the pathophysiology of COPD. The concentrations of TNF-á, CXCL8 and big ET-1 were not statistically different between the experimental groups. No significant differences for the measured analytes were found between smokers and the non-smokers in the control group. The Spearman coefficient of correlation between the concentrations of TNF-á and CXCL8 was r = 0.638 (p<0.0001). However, the concentration of hsCRP was significantly higher in patients with COPD than in the control group (p = 0.0004). hsCRP proved to be a more sensitive diagnostic parameter than TNF-á, CXCL8 and big ET-1 in the systemic circulation in patients with COPD.

Ključne riječi
COPD; TNF-alpha; CXCL8; big ET-1; hsCRP

Hrčak ID: 23450

URI
https://hrcak.srce.hr/23450

Posjeta: 1.122 *