Psychiatria Danubina, Vol. 31 No. 2, 2019.
Pregledni rad
https://doi.org/10.24869/psyd.2019.141
IS BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) VAL66MET POLYMORPHISM ASSOCIATED WITH OBSESSIVE-COMPULSIVE DISORDER? A META-ANALYSIS
Shengdong Wang
orcid.org/0000-0003-4070-9623
; The Molecular Biology Laboratory, Hangzhou Seventh People’s Hospital, Hangzhou, China; Mental Health Center, Zhejiang University School of Medicine, Hangzhou, China
Xiaohong Xu
; Mental Health Center, Zhejiang University School of Medicine, Hangzhou, China; Department of Geriatric Psychiatry, Hangzhou Seventh People’s Hospital, Hangzhou, China
Pan Yan
; The Molecular Biology Laboratory, Hangzhou Seventh People’s Hospital, Hangzhou, China; Mental Health Center, Zhejiang University School of Medicine, Hangzhou, China
Mingfeng Song
; The Molecular Biology Laboratory, Hangzhou Seventh People’s Hospital, Hangzhou, China; Mental Health Center, Zhejiang University School of Medicine, Hangzhou, China
Jing Li
; The Molecular Biology Laboratory, Hangzhou Seventh People’s Hospital, Hangzhou, China; Mental Health Center, Zhejiang University School of Medicine, Hangzhou, China
Shuqi Wang
; The Molecular Biology Laboratory, Hangzhou Seventh People’s Hospital, Hangzhou, China; Mental Health Center, Zhejiang University School of Medicine, Hangzhou, China
Sažetak
Background: Brain-derived neurotrophic factor (BDNF) polymorphism plays an important role in neural survival and was proposed to be related to obsessive-compulsive disorder (OCD). Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in OCD have produced inconsistent results. A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with OCD and age-matched controls.
Subjects and methods: Electronic databases were searched for eligible articles in English and ten studies on the association of the BDNF Val66Met polymorphism with OCD were analysed.
Results: A total of ten studies involving 2306 cases with OCD and 4968 healthy controls were included. Findings indicated that the BDNF Val66Met polymorphism was not associated with OCD. But there was a marginally significant effect of the BDNF Val66Met variant on OCD in different ethnicity.
Conclusion: Findings from this meta-analytic investigation of published literature provide little support for the Val66Met variant of BDNF as a predictor of OCD. Future well-powered agnostic genome-wide association studies with more refined phenotype are needed to clarify genetic influences on OCD.
Ključne riječi
BDNF; Val66Met; obsessive-compulsive disorder; OCD; meta-analysis
Hrčak ID:
235059
URI
Datum izdavanja:
9.7.2019.
Posjeta: 536 *