Izvorni znanstveni članak

https://doi.org/10.20471/acc.2019.58.04.06

Safety and Effects of Crataegus Extract WS 1442 and Nordic Walking on Lipid Profile and Endothelial Function: a Randomized, Partially Blinded Pilot Study in Overweight Volunteers

David Niederseer ; University Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, Institute of Sports Medicine of the State of Salzburg, Salzburg, Austria
Eveline Ledl-Kurkowski ; University Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, Institute of Sports Medicine of the State of Salzburg, Salzburg, Austria
Klara Kvita ; University Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, Institute of Sports Medicine of the State of Salzburg, Salzburg, Austria
Petra Funk ; Clinical Research Department, Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany
Josef Niebauer ; University Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, Institute of Sports Medicine of the State of Salzburg, Salzburg, Austria

Sažetak

Overweight and physical inactivity adversely affect endothelial function and are risk factors for atherosclerosis and cardiovascular disease. Both Crataegus extract WS 1442 and physical exercise exert beneficial effects on endothelial function. We investigated whether WS 1442 and Nordic walking (NW) had comparable effects on endothelial function and lipid profile in overweight subjects. In this partially blinded pilot study, overweight, otherwise healthy volunteers aged 45-75 years were randomized into four groups as follows: WS 1442 2x450 mg/day (WS-standard), WS 1442 2x900 mg/day (WS-double), exercise 2x30 minutes/week (NW-low), and exercise 4x45 minutes/week (NW-high) for 12 weeks. Safety was assessed based on adverse events. Endothelial function testing (EndoPAT®), assessment of endothelial progenitor cells, lipid profiles, and treadmill testing were performed.
Sixty subjects participated in the study. At baseline, subjects in WS-standard/-double groups had higher lipid levels and greater impairment of endothelial function. Subjects with impaired endothelial function showed improvement regardless of the type of intervention. Subjects in WS-standard and WS-double groups showed a trend towards modest decrease in triglycerides and modest increase in HDL-cholesterol; most changes were within the normal limits. In NW-low/-high groups, values
also remained within the normal range. Exercise capacity improved in both NW groups. WS-double showed no additional benefits over WS-standard. All adverse events were unrelated or improbably related to treatment. In conclusion, WS 1442 and exercise training were safe and showed beneficial effects on endothelial function and lipid profile in overweight but otherwise healthy volunteers; exercise capacity improved only by Nordic walking.

Ključne riječi

Crataegus extract WS 1442; Exercise; Overweight; Endothelial progenitor cells

Hrčak ID:

235117

URI

https://hrcak.srce.hr/235117

Datum izdavanja:

1.12.2019.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.067 *