CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA:
PREVALENCE AND CLINICAL CHARACTERISTICS
; Department of Biostatistics & Medical Informatics, Cerrahpa????a Faculty of Medicine Istanbul University, Istanbul, Turkey; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester
Elnour E. Dafeeah
; Department of Psychiatry, Rumeilah Hospital, Hamad Medical Corporation, Doha, Qatar
Mohammed T. Abou-Saleh
; Addiction Research Group, Division of Mental Health, St George's University of London, Cranmer Terrace, London, UK
; Department of Psychiatry, HSPRD, Institute of Psychiatry, King's College London, London, UK
; Deptartment of Clinical & Experimental Medicine, University of Foggia, Foggia, Italy
APA 6th Edition Bener, A., E. Dafeeah, E., T. Abou-Saleh, M., Bhugra, D. i Ventriglio, A. (2020). CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA:
PREVALENCE AND CLINICAL CHARACTERISTICS. Psychiatria Danubina, 32 (1), 78-83. https://doi.org/10.24869/psyd.2020.78
MLA 8th Edition Bener, Abdulbari, et al. "CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA:
PREVALENCE AND CLINICAL CHARACTERISTICS." Psychiatria Danubina, vol. 32, br. 1, 2020, str. 78-83. https://doi.org/10.24869/psyd.2020.78. Citirano 04.08.2020.
Chicago 17th Edition Bener, Abdulbari, Elnour E. Dafeeah, Mohammed T. Abou-Saleh, Dinesh Bhugra i Antonio Ventriglio. "CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA:
PREVALENCE AND CLINICAL CHARACTERISTICS." Psychiatria Danubina 32, br. 1 (2020): 78-83. https://doi.org/10.24869/psyd.2020.78
Harvard Bener, A., et al. (2020). 'CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA:
PREVALENCE AND CLINICAL CHARACTERISTICS', Psychiatria Danubina, 32(1), str. 78-83. https://doi.org/10.24869/psyd.2020.78
Vancouver Bener A, E. Dafeeah E, T. Abou-Saleh M, Bhugra D, Ventriglio A. CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA:
PREVALENCE AND CLINICAL CHARACTERISTICS. Psychiatria Danubina [Internet]. 2020 [pristupljeno 04.08.2020.];32(1):78-83. https://doi.org/10.24869/psyd.2020.78
IEEE A. Bener, E. E. Dafeeah, M. T. Abou-Saleh, D. Bhugra i A. Ventriglio, "CO-MORBIDITY BETWEEN MAJOR DEPRESSION AND SCHIZOPHRENIA:
PREVALENCE AND CLINICAL CHARACTERISTICS", Psychiatria Danubina, vol.32, br. 1, str. 78-83, 2020. [Online]. https://doi.org/10.24869/psyd.2020.78
Sažetak Backround: The aim of this study was to explore the co-morbidity between Major Depressive Disorder (MDD) and Schizophrenia (SZ) among a large number of patients describing their clinical characteristics and rate of prevalence.
Subjects and methods: A cohort-study was carried out on 396 patients affected by MDD and SZ who consecutively attended the Department of Psychiatry, Rumeilah Hospital in Qatar. We employed the World Health Organization - Composite International Diagnostic Interview (WHO CIDI) and the Structured Clinical Interview for DSM-5 (SCID-5) for diagnoses. Patients were also grouped in MDD patients with and without co-morbid SZ (MDD vs MDD/SZ) for comparisons.
Results: A total of 396 subjects were interviewed. MDD patients with comorbid SZ (146(36.8%)) were 42.69±14.33 years old whereas MDD without SZ patients (250 (63.2%)) aged 41.59±13.59. Statistically significant differences between MDD with SZ patients and MDD without SZ patients were: higher BMI (Body Mass Index) (p=0.025), lower family income (p=0.004), higher rate of cigarette smoking (p<0.001), and higher level of consanguinity (p=0.023). Also, statistically significant differences were found in General Health Score (p=0.017), Clinical Global Impression-BD Score (p=0.042), duration of illnesses (p=0.003), and Global Assessment of Functioning (p=0.012). Rates of anxiety dimensions (e.g.: general anxiety, agoraphobia, somatisation, etc.), mood dimensions (e.g.: major depression, mania, oppositional defiant behaviour, Bipolar disorder), Attention Deficit Hyperactivity Disorder, psychotic and personality dimensions were higher among MDD with SZ patients than MDD without SZ.
Conclusion: This study confirms that MDD with SZ is a common comorbidity especially among patients reporting higher level of consanguinity. MDD/SZ comorbidity presents unfavourable clinical characteristics and higher levels of morbidity at rating scales.