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https://doi.org/10.20471/LO.2020.48.01.04

Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?

Ana Tečić-Vuger   ORCID icon orcid.org/0000-0003-2203-161X ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Robert Šeparović   ORCID icon orcid.org/0000-0002-4002-2699 ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; Medical School, University of Juraj Dobrila, Pula, Croatia
Ljubica Vazdar ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mirjana Pavlović ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Petra Lepetić ; Medical Oncology Department, Division for Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Sanda Šitić ; Department of Oncological Pathology and Clinical Cytology, 'Ljudevit Jurak' University Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Božena Šarčević ; School of Medicine, University of Zagreb, Zagreb, Croatia
Damir Vrbanec ; Medical School, University of Juraj Dobrila, Pula, Croatia

Puni tekst: engleski, pdf (385 KB) str. 20-26 preuzimanja: 131* citiraj
APA 6th Edition
Tečić-Vuger, A., Šeparović, R., Vazdar, Lj., Pavlović, M., Lepetić, P., Šitić, S., ... Vrbanec, D. (2020). Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?. Libri Oncologici, 48 (1), 20-26. https://doi.org/10.20471/LO.2020.48.01.04
MLA 8th Edition
Tečić-Vuger, Ana, et al. "Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?." Libri Oncologici, vol. 48, br. 1, 2020, str. 20-26. https://doi.org/10.20471/LO.2020.48.01.04. Citirano 19.06.2021.
Chicago 17th Edition
Tečić-Vuger, Ana, Robert Šeparović, Ljubica Vazdar, Mirjana Pavlović, Petra Lepetić, Sanda Šitić, Božena Šarčević i Damir Vrbanec. "Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?." Libri Oncologici 48, br. 1 (2020): 20-26. https://doi.org/10.20471/LO.2020.48.01.04
Harvard
Tečić-Vuger, A., et al. (2020). 'Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?', Libri Oncologici, 48(1), str. 20-26. https://doi.org/10.20471/LO.2020.48.01.04
Vancouver
Tečić-Vuger A, Šeparović R, Vazdar Lj, Pavlović M, Lepetić P, Šitić S i sur. Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?. Libri Oncologici [Internet]. 2020 [pristupljeno 19.06.2021.];48(1):20-26. https://doi.org/10.20471/LO.2020.48.01.04
IEEE
A. Tečić-Vuger, et al., "Androgen receptors: unclear ubiquitious mechanism or the missing key in the triple–negative breast cancer?", Libri Oncologici, vol.48, br. 1, str. 20-26, 2020. [Online]. https://doi.org/10.20471/LO.2020.48.01.04

Sažetak
Androgen receptors (AR) are ligand-dependent nuclear transcription factors. These are steroid receptors, similar to estrogen receptors (ER). They are expressed in numerous cells in the body, with different constructive roles. AR signalling can be involved in the development of a variety of human malignant tumors, such as prostate cancer, bladder, liver, salivary glands, kidney, lung, melanoma, sarcoma, breast cancer, and many others. The role of AR is most clear and today best explained in prostate cancer. The mechanism of AR signalling in other human epithelial tumors is still quite unclear and the effects are different to entirely opposite in different tumors. In breast cancer, AR are the most commonly expressed receptors, but still with an incompletely clear role, prognostic and predictive significance. The expression of AR in triple-negative breast cancer (TNBC) is highly variable. Despite the marked differences in the results of the various analyzes, they appear to have a beneficial effect on the prognosis and are potentially the target of antihormone therapy for treatment of TNBC in the future.

Ključne riječi
androgen receptors; prostate cancer; breast cancer; triple–negative breast cancer

Hrčak ID: 240534

URI
https://hrcak.srce.hr/240534

[hrvatski]

Posjeta: 372 *