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https://doi.org/10.17535/crorr.2020.0010

Parameter identification in the mathematical model of glucose and insulin tolerance test - the mathematical markers of diabetes

Marija Heffer ; Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia
Vedrana Ivić   ORCID icon orcid.org/0000-0002-8185-1960 ; Faculty of Medicine, J. J. Strossmayer University of Osijek, Osijek, Croatia
Rudolf Scitovski   ORCID icon orcid.org/0000-0002-7386-5991 ; Department of Mathematics, J. J. Strossmayer University of Osijek, Osijek, Croatia

Puni tekst: engleski, pdf (495 KB) str. 121-133 preuzimanja: 210* citiraj
APA 6th Edition
Heffer, M., Ivić, V. i Scitovski, R. (2020). Parameter identification in the mathematical model of glucose and insulin tolerance test - the mathematical markers of diabetes. Croatian Operational Research Review, 11 (1), 121-133. https://doi.org/10.17535/crorr.2020.0010
MLA 8th Edition
Heffer, Marija, et al. "Parameter identification in the mathematical model of glucose and insulin tolerance test - the mathematical markers of diabetes." Croatian Operational Research Review, vol. 11, br. 1, 2020, str. 121-133. https://doi.org/10.17535/crorr.2020.0010. Citirano 18.10.2021.
Chicago 17th Edition
Heffer, Marija, Vedrana Ivić i Rudolf Scitovski. "Parameter identification in the mathematical model of glucose and insulin tolerance test - the mathematical markers of diabetes." Croatian Operational Research Review 11, br. 1 (2020): 121-133. https://doi.org/10.17535/crorr.2020.0010
Harvard
Heffer, M., Ivić, V., i Scitovski, R. (2020). 'Parameter identification in the mathematical model of glucose and insulin tolerance test - the mathematical markers of diabetes', Croatian Operational Research Review, 11(1), str. 121-133. https://doi.org/10.17535/crorr.2020.0010
Vancouver
Heffer M, Ivić V, Scitovski R. Parameter identification in the mathematical model of glucose and insulin tolerance test - the mathematical markers of diabetes. Croatian Operational Research Review [Internet]. 2020 [pristupljeno 18.10.2021.];11(1):121-133. https://doi.org/10.17535/crorr.2020.0010
IEEE
M. Heffer, V. Ivić i R. Scitovski, "Parameter identification in the mathematical model of glucose and insulin tolerance test - the mathematical markers of diabetes", Croatian Operational Research Review, vol.11, br. 1, str. 121-133, 2020. [Online]. https://doi.org/10.17535/crorr.2020.0010

Sažetak
Glucose tolerance test (GTT) is standard diagnostic procedure that tests the efficiency of blood glucose-lowering hormones (insulin, incretins, leptin). Contrary, insulin tolerance test (ITT) is probing efficiency of blood glucose-rising hormones (glucagon, thyroxine, growth hormone, glucocorticoids, adrenalin, noradrenalin). These two hormone systems together maintain blood glucose levels in a narrow range. Various pathophysiological mechanisms give rise to a reversible condition - prediabetes which then progresses to an irreversible chronic disease - diabetes, both marked with deviation of blood glucose levels outside the set range. In diagnostic purpose, the patient is given glucose load, and blood glucose is measured right before and 2 hours after load. Measurements are more frequent after insulin injection (ITT) or if both tests are performed on experimental animals. In this paper we analyse the mathematical model for GTT and ITT. The obtained model function is an useful tool in describing the dynamics of blood glucose changes.

Ključne riječi
glucose tolerance test; insulin tolerance test; mathematical model; parameter identification

Hrčak ID: 240688

URI
https://hrcak.srce.hr/240688

Posjeta: 449 *