Izvorni znanstveni članak

https://doi.org/10.2478/acph-2021-0029

Ilex paraguariensis extract as drugs alternative for pain

LUCIANA C. NOWACKI ; Pharmacology Department, Tuiuti University of Paraná, Curitiba, PR, Brazil
JOSÉ STECHMAN-NETO ; Postgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, PR, Brazil
ELBERTH M. SCHIEFER ; Graduate Program in Electrical and Computer Engineering, Federal Technological University of Paraná Curitiba, PR, Brazil
ANDRESSA F. SANTOS ; Clinical Analysis Department, Federal University of Paraná, Curitiba, PR, Brazil
ANDRÉA E. M. STINGHEN ; Basic Pathology Department, Federal University of Paraná, Curitiba, PR, Brazil
GUILHERME L. SASSAKI ; Biochemistry Department, Federal University of Paraná, Curitiba, PR, Brazil
LAURO M. DE SOUZA ; Pequeno Principe College, Pelé Pequeno Principe Research Institute, Curitiba, PR, Brazil
KILLIAN E. CRISTOFF ; Postgraduate Program in Communication Disorders, Tuiuti University of Paraná, Curitiba, PR, Brazil
WESLE M. DE SOUZA ; Clinical Analysis Department, Federal University of Paraná, Curitiba, PR, Brazil

Sažetak

Pain is a common and distressing symptom of many diseases and its clinical treatment generally involves analgesics and anti-inflammatory drugs. This study evaluated the toxicity of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae) aqueous extract (leaves, petioles and branches) and its performance in nociceptive response. Hepatotoxicity, psychostimulant test and evaluation of enzyme markers for liver damage were also tested. Chromatographic analysis by UPLC-MS demonstrated a series of isomeric monocaffeoylquinic acids, isomers of dicaffeoylquinic acids, flavonol glycosides, and saponins. Phase I and II of nociception were obtained for meloxicam, dexamethasone and aqueous Ilex paraguariensis extract. Ilex paraguariensis extract concentration was negatively correlated (R = –0.887) with alanine aminotransferase (p < 0.05) in acetaminophen-induced hepatotoxicity test, indicating an hepatoprotective activity of this extract. Ilex paraguariensis extract also presented analgesic properties equivalent to drugs that already have proven efficacy. Notably, administration of multiple doses of Ilex paraguariensis extract was considered safe from the therapeutic point of view.

Ključne riječi

nociception; pain; hepatoprotection; toxicity; Ilex paraguariensis; aqueous extract; UPLC-MS

Hrčak ID:

243895

URI

https://hrcak.srce.hr/243895

Datum izdavanja:

30.9.2021.

Posjeta: 1.478 *