Short communication, Note

https://doi.org/10.2478/acph-2021-0030

Effect of sacubitril/valsartan on inflammation and oxidative stress in doxorubicin-induced heart failure model in rabbits

CHUN YU ; Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, Jilin China,132103
DONGHAO LI ; Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, Jilin China,132103
ZHONGYAN LI ; Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, Jilin China,132103
DONGHUI YU ; Department of Cardiovascular Internal Medicine, Affiliated Hospital of Jilin Medical College, Jilin China,132103
GUIJUAN ZHAI ; Department of Radiology, Affiliated Hospital of Jilin Medical College, Jilin China, 132103

Abstract

Our study evaluates the effects of sacubitril/valsartan (SAC/VAL) in the rabbit model of doxorubicin-induced heart failure. Twenty rabbits (5 per group) were administered with doxorubicin (DOX, 1.5 mg kg–1, i.v.) to induce heart failure. Specific biomarkers such as BNP, CnT, CRP and ROMs were determined. The cardiac enzymatic antioxidant systems were recorded with their electrographic profiles. HR, SBP, DBP and MAP were restored at 5 or 10 mg kg–1 (p.o.) of SAC/VAL compared to DOX, followed by reduced levels of creatinine and BNP (p < 0.001). Significant improvements (p < 0.05) compared to DOX were also noticed in CAT, SOD and LPO with the same doses of SAC/VAL. Specific biomarkers such as BNP, CnT, CRP and ROMs descended significantly (p < 0.001) with treatment when compared to their baseline values. Our findings implied that SAC/VAL treatment reduced the inflammation and oxidative stress to improve the cardiac function.

Keywords

sacubitril; valsartan; doxorubicin-heart failure; inflammation; oxidative stress; natriuretic peptide

Hrčak ID:

245056

URI

https://hrcak.srce.hr/245056

Publication date:

30.9.2021.

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