Stručni rad
https://doi.org/10.20471/acc.2020.59.s1.16
Skip Metastases in Papillary Thyroid Carcinoma – Prevalence, Predictive and Clinicopathological Factors
Borna Miličić
orcid.org/0000-0002-4221-7334
; Department of Ear, Nose, Throat, and Head and Neck Surgery, Zagreb University Hospital Centre
Ratko Prstačić
orcid.org/0000-0003-3623-3562
; Department of Ear, Nose, Throat, and Head and Neck Surgery, Zagreb University Hospital Centre; School of Medicine, University of Zagreb
Drago Prgomet
; Department of Ear, Nose, Throat, and Head and Neck Surgery, Zagreb University Hospital Centre; School of Medicine, University of Zagreb
Sažetak
Cervical lymph node metastases are frequently found in papillary
thyroid carcinoma (PTC) and occur in a stepwise fashion. Skip metastases that omit the central compartment
and spread initially in lateral neck levels are present in a certain share of patients, and their
significance is poorly understood. The aim of this prospective study was to identify their possible
predictors and clinicopathological factors in a group of patients with PTC with lateral lymph node
(LLN ) metastases. Methods: We enrolled 68 patients with PTC with preoperatively evaluated LLN
metastases who underwent total thyroidectomy with lateral lymph node dissection between 2011 and
2018. We analysed the clinicopathological features and pattern of dissemination of continuous and
skip metastases. Results: The prevalence of skip metastases was 23.5%. Compared with the continuous
metastases group, the patients were older, had primary tumors that were more often situated unilaterally,
and had smaller primary tumor size. Level II was less often involved, and none of the patients
with skip metastases had all LNN positive (p = 0.05). Conclusion: Skip metastases occur more frequently
in older patients and display certain clinicopathological features like smaller size of the primary
tumor and dissemination in less lateral neck levels. In the view of the fact that they are found
rather frequently, lateral neck regions should be meticulously investigated in patients with PTC without
central lymph node (CLL ) metastases.
Ključne riječi
skip metastases; clinicopathological features; papillary thyroid carcinoma; lateral neck metastases
Hrčak ID:
248281
URI
Datum izdavanja:
1.11.2020.
Posjeta: 5.182 *