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Preparation of O-Alkyl-N-acyl-DL-serines

N. Štimac ; Research Department, .»Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia
B. Gašpet ; Research Department, .»Pliva« Pharmaceutical and Chemical Works, Zagreb, Croatia, Yugoslavia

Sažetak

N-Phthaloyl amino acids have proved to be very useful for the syntheses of peptides, diazoketones, homologous optically active B-amino acids, optically active a-amino aldehydes, aminoalkylglyoocals and vinylogs of naturally occurring amino acids. As no description has hitherto been given of the N-phthaloyl derivatives of O-alkyl-DL-serine which would enable the above mentioned syntheses to be carried out with serine, we prepared O-methyl-N-phthaloyl-DL-serine by reacting O-methyl-DL-serine and O-ethyl-DL-serine respectively with phthalic anhydride. Further more, O-ethyl-N-p-tosyl-DL-serine and N-carbobenzoxy-O-ethyl -DL-serine were also prepared.

Ključne riječi

Hrčak ID:

249466

URI

https://hrcak.srce.hr/249466

Datum izdavanja:

31.7.1954.

Posjeta: 522 *