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Synthesis of the Homologue of L-Leucine (Synthesis of-β-Amino-D-methyl-caproic Acid)

K. Balenović ; Chemical Institute, Faculty of Science, Zagreb, Croatia
D. Brovet-Keglević ; Chemical Institute, Faculty of Science, Zagreb, Croatia


Puni tekst: engleski pdf 5.624 Kb

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preuzimanja: 24

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Sažetak

It has been shown that N-Phthalyl-derivatives of a-amino- acids can be converted into the corresponding diazoketones. We have applied this reaction to the preparation of the homologue of L-leucine by the Arndt-Eistert synthesis from the hitherto undescribed diazoketone of N-phthalyl-L-leucine (I), Methanolic solution of (I) heated with silver oxyde yielded the optically active ester of the homologous acid (Il), which, refluxed with hydriodic acid, gave the free, optically active B-amino acid (III).

Ključne riječi

Hrčak ID:

249921

URI

https://hrcak.srce.hr/249921

Posjeta: 82 *