Pregledni rad

Tophaceous Gout – When the Skin Comes First

Carmen Salavastru ; Paediatric Dermatology Department, Colentina Clinical Hospital
Fabiola Iuliana Copaci ; “Unirea” Medical Centre, Bucharest, Romania
Daniela Vrinceanu ; “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Adelina Maria Sendrea ; Paediatric Dermatology Department, Colentina Clinical Hospital
George Sorin Tiplica ; 2nd Dermatology Clinic, Colentina Clinical Hospital

Sažetak

Gout represents a metabolic disorder with systemic
echo, in which needle-like crystals of monosodium urate are deposited
in various tissular structures. Crystals accumulation in the
connective tissue (tophi) represents the late, chronic stage of this
disease, usually emerging after an average of 10 years after disease
onset. Herein we report three cases of patients aged 70, 33, and 53
who presented with painful subcutaneous nodules located on various
body areas. All of them had hyperuricemia. Several conditions
had to be investigated in order to establish the etiology of uric acid
metabolism alterations. Laboratory and pathology findings established
the diagnosis of gout, with tophi as the first symptom of the
disease. Following patient education, diet and lifestyle changes,
and medication, the outcome in all patients was favorable, with alleviation
of the symptoms. Tophaceous gout as a first presentation
of this disease is currently uncommon, but dermatologist should
be aware of this rare finding for proper management of such cases
and to prevent the resultant significant functional and quality of
life impairment if not recognized early.

Ključne riječi

tophaceous gout, hyperuricemia, gout

Hrčak ID:

255076

URI

https://hrcak.srce.hr/255076

Datum izdavanja:

30.12.2020.

Posjeta: 1.187 *