Skoči na glavni sadržaj

Sažetak sa skupa

Infectious endocarditis in disguise: a case series of spondylodiscitis as a presentation of endocarditis

Ana Marija Slišković orcid id
Vlatka Rešković Lukšić orcid id
Sandra Jakšic Jurinjak orcid id
Blanka Glavaš Konja orcid id
Marina Prpić orcid id
Zvonimir Ostojić orcid id
Marija Brestovac orcid id
Martina Lovrić Benčić orcid id
Maja Hrabak-Paar orcid id
Joško Bulum orcid id
Jadranka Šeparović Hanževački orcid id

Puni tekst: engleski pdf 749 Kb

str. 192-193

preuzimanja: 157


Preuzmi JATS datoteku


Ključne riječi

endocarditis, septic embolizations, spondylodiscitis

Hrčak ID:



Posjeta: 378 *

Introduction: Infective endocarditis is related to a wide range of complications including septic embolizations such as spondylodiscitis. Risk factors associated with systemic include left-sided vegetation, large vegetation size, microbiology, age, diabetes, etc (1). Endocarditis masked by such complications might be difficult to diagnose and lead to invalid and late treatment which in turn results in increased morbidity and mortality (2).

Case report: During one year period we observed three cases of endocarditis complicated with severe form of spondylodiscitis leading to immobilization and prolonged rehabilitation. Two out of three patients underwent surgical procedure. First patient, a 66-year-old female was admitted to our department due to E. faecalis aortic valve endocarditis and consequently moderate aortic regurgitation (Figure 1 A). Few years preceding the initial presentation, patient was hospitalized in our institution because of non-ischemic cardiomyopathy and implantable cardioverter defibrillator (ICD) was implanted for primary prevention of sudden cardiac death. During routine follow-up patient complained about general weakness, weight loss, fever and chills and limited walking ability caused by lumbar back pain. On echocardiogram, ICD lead-associated thrombus was described, although patient was already receiving oral anticoagulant therapy for atrial fibrillation. Three months after that, patient was hospitalized once again and endocarditis was confirmed. Clinical presentation was complicated not only with spondylodiscitis and paraparesis but also with septic emboli to the right kidney which was initially believed to be tumor. Following PET CT and MR scan, infection of ICD electrodes together with L3/L4 spondylodiscitis were revealed (Figure 1 B, C). Second patient, a 48-year-old male was evaluated because of recurrent fever, hypergammaglobulinemia and sacral pain. Multiple myeloma was suspected and investigated to be the cause of patient’s disability, when blood cultures, along with echocardiography, confirmed diagnosis of Aggregatibacter aphrophilus mitral valve endocarditis resulting in severe mitral regurgitation (Figure 2 A). MR scan was performed due to long standing lumbar pain - L5-S1 spondylodiscitis was described and treated with prolonged antibiotic therapy (Figure 2 B). Third patient, a 52-year-old man is still hospitalized in our institution due to Gemella morbillorum sepsis, aortic valve endocarditis and thoracic spondylodiscitis (Figure 3 A). He was initially treated for 6-weeks with antibiotics, however, clinical course was complicated by vancomycin-induced DRESS syndrome along with acute kidney injury which required renal replacement therapy. PET CT scan reported resolution of aortic valve inflammation, but active metabolism was detected in thoracic spine in Th6 (Figure 3 B). Even though tremendous effort is exerted to improve patient’s condition, his full recovery is very uncertain.

FIGURE 1 Aortic vegetation on transthoracic echocardiography (A), infection of electrodes and L3-4 spondylodiscitis on PET CT (B) and on MR scan (C).
FIGURE 2 Mitral valve endocarditis described on 3D TEE (A) with L5-S1 spondylodiscitis (B) on MR scan caused by Aggregatibacter.
FIGURE 3 Th 5-7 spondylodiscitis in a patient with Gemella morbillorum aortic valve endocarditis shown on a MR scan (A) and on PET CT (B).

Conclusion: Septic embolism due to infective endocarditis warrants multidisciplinary team approach, prolonged antimicrobial therapy and surgery as a definitive treatment in most of the cases. Early diagnosis and treatment are highly important because any delay may lead to life-threatening, long-term sequelae and prolonged rehabilitation.



Hubert S, Thuny F, Resseguier N, Giorgi R, Tribouilloy C, Le Dolley Y, et al. Prediction of symptomatic embolism in infective endocarditis: construction and validation of a risk calculator in a multicenter cohort. J Am Coll Cardiol. 2013 October 8;62(15):1384–92. PubMed:


Cabell CH, Pond KK, Peterson GE, Durack DT, Corey GR, Anderson DJ, et al. The risk of stroke and death in patients with aortic and mitral valve endocarditis. Am Heart J. 2001 July;142(1):75–80. PubMed:

This display is generated from NISO JATS XML with jats-html.xsl. The XSLT engine is libxslt.