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Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker

Elvira Mustać
Gordana Zamolo
Marija Petković
Gordana Đorđević
Jelena Radić
Emina Grgurević
Tanja Batinac

Puni tekst: engleski, pdf (221 KB) str. 741-746 preuzimanja: 668* citiraj
APA 6th Edition
Mustać, E., Zamolo, G., Petković, M., Đorđević, G., Radić, J., Grgurević, E. i Batinac, T. (2008). Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker. Collegium antropologicum, 32 (3), 741-746. Preuzeto s https://hrcak.srce.hr/27056
MLA 8th Edition
Mustać, Elvira, et al. "Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker." Collegium antropologicum, vol. 32, br. 3, 2008, str. 741-746. https://hrcak.srce.hr/27056. Citirano 24.10.2021.
Chicago 17th Edition
Mustać, Elvira, Gordana Zamolo, Marija Petković, Gordana Đorđević, Jelena Radić, Emina Grgurević i Tanja Batinac. "Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker." Collegium antropologicum 32, br. 3 (2008): 741-746. https://hrcak.srce.hr/27056
Harvard
Mustać, E., et al. (2008). 'Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker', Collegium antropologicum, 32(3), str. 741-746. Preuzeto s: https://hrcak.srce.hr/27056 (Datum pristupa: 24.10.2021.)
Vancouver
Mustać E, Zamolo G, Petković M, Đorđević G, Radić J, Grgurević E i sur. Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker. Collegium antropologicum [Internet]. 2008 [pristupljeno 24.10.2021.];32(3):741-746. Dostupno na: https://hrcak.srce.hr/27056
IEEE
E. Mustać, et al., "Breast Infiltrating Ductal Carcinoma: Analysis of Hormone, HER-2 Receptors and Ki-67 Proliferation Marker", Collegium antropologicum, vol.32, br. 3, str. 741-746, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/27056. [Citirano: 24.10.2021.]

Sažetak
The aim of this study was to analyse breast carcinomas with discordant receptor status, probably hormonal dependent
(estrogen receptor (ER) positive, progesterone receptor (PR) negative or ER-PR+ subgroup profile) infiltrating ductal
breast carcinomas not otherwise specified (IDC NOS). Specimens from 90 IDC NOS were grouped into three categories
according to hormonal status: dependent (D) (ER+PR+), probably dependent (PD) (ER+PR- or ER-PR+) and non-dependent
(ND) (ER-PR-); they were evaluated considering some established prognostic parameters in breast carcinomas.
Statistically significant difference was found between tumor receptor status distribution and menopausal status (p=
0.0235), age of the patients (p=0.000467), histological grade (p=0.000003), vascular invasion (p=0.006), HER-2 status
(p=0.0039) and Ki-67 proliferation rate (p=0.000311). D tumors were found exclusively in post-menopausal patients
(average age 68.9 years), most of which had intermediate (II) grade, without vascular invasion, with HER-2 status score
predominantly 0 or 1+ and lower Ki-67 proliferation rate. PD tumors were found predominantly in younger post-menopausal
patients (average age 57.5 years), with vascular invasion found in 23% of the cases. ND tumors mostly had higher
histological grade, showed the highest percentage of the Ki-67 positive tumor cells and vascular invasion in 30% of the
cases. We conclude that the patients with PD breast carcinomas were younger post-menopausal women with the tumors
moderately differentiated, HER-2 score 0 or 1+ and with lower Ki-67 proliferation rate.

Ključne riječi
breast carcinoma; hormone receptors; menopausal status; HER-2; Ki-67

Hrčak ID: 27056

URI
https://hrcak.srce.hr/27056

Posjeta: 905 *