APA 6th Edition Aurer, I., Lauc, G., Dumić, J., Rendić, D., Matišić, D., Miloš, M., ... Labar, B. (2007). Aberrant Glycosylation of Igg Heavy Chain in Multiple Myeloma. Collegium antropologicum, 31 (1), 247-251. Preuzeto s https://hrcak.srce.hr/27277
MLA 8th Edition Aurer, Igor, et al. "Aberrant Glycosylation of Igg Heavy Chain in Multiple Myeloma." Collegium antropologicum, vol. 31, br. 1, 2007, str. 247-251. https://hrcak.srce.hr/27277. Citirano 20.06.2021.
Chicago 17th Edition Aurer, Igor, Gordan Lauc, Jerka Dumić, Dubravko Rendić, Danica Matišić, Marija Miloš, Marija Heffer-Lauc, Mirna Flogel i Boris Labar. "Aberrant Glycosylation of Igg Heavy Chain in Multiple Myeloma." Collegium antropologicum 31, br. 1 (2007): 247-251. https://hrcak.srce.hr/27277
Harvard Aurer, I., et al. (2007). 'Aberrant Glycosylation of Igg Heavy Chain in Multiple Myeloma', Collegium antropologicum, 31(1), str. 247-251. Preuzeto s: https://hrcak.srce.hr/27277 (Datum pristupa: 20.06.2021.)
Vancouver Aurer I, Lauc G, Dumić J, Rendić D, Matišić D, Miloš M i sur. Aberrant Glycosylation of Igg Heavy Chain in Multiple Myeloma. Collegium antropologicum [Internet]. 2007 [pristupljeno 20.06.2021.];31(1):247-251. Dostupno na: https://hrcak.srce.hr/27277
IEEE I. Aurer, et al., "Aberrant Glycosylation of Igg Heavy Chain in Multiple Myeloma", Collegium antropologicum, vol.31, br. 1, str. 247-251, 2007. [Online]. Dostupno na: https://hrcak.srce.hr/27277. [Citirano: 20.06.2021.]
Sažetak Although the majority of eukaryotic proteins are glycosylated, there is a dearth of knowledge regarding protein sugar
moieties and their changes in disease. Most multiple myeloma cases are characterized by production of monoclonal
immunoglobulins (Ig). We studied galactosylation and sialylation of IgG heavy chains in 16 patients with IgG myeloma
using lectin blotting and densitometry. In comparison to age and sex matched controls, galactosylation was reduced in
multiple myeloma (median 317 vs. 362, range 153–410 vs. 309–447 relative units, p=0.015, Student’s t-test). Sialylation
was stage dependent; samples from patients with stage IIA had lowest amounts of sialic acid, IIIA intermediate and IIIB
highest (142.6 vs. 185.9 vs. 248.5 relative units, correlation coefficient r=0.55). Both galactosylation and sialylation levels
were independent of age, sex, treatment type, response to treatment, disease duration and IgG and b2 microglobulin
concentration. These data indicate that multiple myeloma is characterized by aberrant immunoglobulin glycosylation.