Izvorni znanstveni članak
Long-Term Exposure to Solar Ultraviolet Radiation as a Risk Factor for Age-Related Macular Degeneration
Ivna Pleština-Borjan
Mery Klinger-Lasić
Sažetak
A clinical epidemiological study has been conducted as a part of research project investigating chronic exposure to solar
ultraviolet radiation (UVR) as a factor contributing to the onset of age-related macular degeneration (ARMD). The
study included 623 subjects older than 50 from two different geographic areas, one with high solar radiation (the island
of [olta – Region 1) and the other (Zagreb and its surroundings – Region 2) with low solar radiation. Individual exposure
to UVR was assessed according to global exposure to sunlight, on the basis detailed history of life-long exposure to
sunlight, with special reference to professional history and geophysical specificities of the respective areas. Different
grades of ARMD were based on the fundus photographs and flourescein angiography. Statistically significant relation
was found between ARMD and mean daily exposure (in hours) to solar radiation in Region 1 (
2=186.22; p=0.000), Region
2 (
2=25.66; p=0.000) and in both regions together (
2=216.43; p=0.000). ARMD is more frequent in the subjects
belonging to the Region 1 and with the same exposure to sunlight (8 hours and more) which goes in favor of their increased
UVR exposure. The results support a relationship between long-term sunlight exposure and increased risk of
ARMD.
Ključne riječi
ultraviolet radiation; age-related macular degeneration
Hrčak ID:
27418
URI
Datum izdavanja:
16.1.2007.
Posjeta: 1.576 *