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Epidermal Malignant Tumors: Pathogenesis, Influence of UV Light and Apoptosis

Larisa Prpić Massari
Marija Kaštelan
Franjo Gruber

Puni tekst: engleski pdf 83 Kb

str. 83-85

preuzimanja: 552



Basal cell carcinoma and squamous cell carcinoma, collectively termed non-melanoma skin cancers are the most
commonmalignant tumors in humans. Basal cell carcinoma grows slowly and metastatic spread is very rare. Squamous
cell carcinoma is characterized by infiltrative, destructive growth and metastasis. Long-term exposure of skin to UV light
has a great impact on development of these epidermal malignancies. UV light induces cascade of events like well known
DNA damage of keratinocytes as well as still completely undetermined influence on apoptotic process through expression
of proapoptotic and antiapoptotic molecules. The major role in development of skin cancer is given to proapoptotic p53
molecule or tumor suppressor gene which mutation due to UV exposure leads to resistance of DNA-damaged cell to
apoptosis. Other proapoptotic molecules such as Fas ligand (FasL) and tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL) are strongly expressed in basal cell carcinoma and squamous cell carcinoma that could be explained by
the ability of tumor to escape the attack of immune system.

Ključne riječi

basal cell carcinoma; squamous cell carcinoma; ultraviolet light; apoptosis; p53; FasL

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