Stručni rad
Effectiveness of Systemic Therapies in Patients with Obesity and Psoriasis: A Single-center Retrospective Study
Claudio Bonifati
; Centre for the Study and Treatment of Psoriasis at the Department of Clinical Dermatology, San Gallicano Dermatological Institute, Rome, Italy
Roberta Capoccia
; Centre for the Study and Treatment of Psoriasis at the Department of Clinical Dermatology, San Gallicano Dermatological Institute, Rome, Italy
Dario Graceffa
; Centre for the Study and Treatment of Psoriasis at the Department of Clinical Dermatology, San Gallicano Dermatological Institute, Rome, Italy
Aldo Morrone
; Scientific Direction, San Gallicano Dermatological Institute, Rome, Italy
Sažetak
This retrospective study included 63 patients with obesity (Body Mass
Index; BMI ≥ 30) and psoriasis. Our aim was to verify the effectiveness of different
systemic therapies administered to the above cohort of subjects over a period of 1
year. Improvements of 75%, 90%. and 100% compared with the baseline Psoriasis
Area Severity Index (PASI 75, PASI 90, and PASI 100, respectively) were used as clinical
outcome measures. In a median time of 16 weeks, 85.7%, 68.2%, and 38.0% of patients
achieved PASI 75, PASI 90, and PASI 100, respectively. In parallel, the Dermatology
Life Quality Index (DLQI) and the visual analog score for measuring itch intensity
(VAS itch) decreased significantly (P<0.0001 for both parameters). At the achievement
of PASI 75, BMI increased as compared to baseline (P=0.02) and did not significantly
vary at the attainment of PASI 90 and PASI 100 (P= 0.07 for both outcomes).
Logistic multivariate regression analysis showed that treatment with biologic drugs
was a positive predictor for achieving PASI 75, PASI 90, and PASI 100. BMI >31.7 and
the presence of psoriatic arthritis were negative predictors for the achievement of
PASI 90, while having a DLQI >6 was a positive predictor
Ključne riječi
Hrčak ID:
274462
URI
Datum izdavanja:
11.5.2021.
Posjeta: 659 *