Crtice
Genital Human Papillomavirus Infection in Women from the Zagreb Region
Tatjana Marijan
Jasmina Vraneš
Ana Mlinarić-Džepina
Vladimira Leskovar
Jasna Knežević
Matea Kvaternik
Sažetak
Human papillomavirus (HPV) infection is the most common sexually transmitted infection, especially among young,
sexually active individuals. As persistent infection with oncogenic types may lead to cervical cancer, HPV testing is a useful
tool to screen for women at risk for subsequent development of cervical cancer. The aim of the study was to determine
the prevalence of high-risk HPV (hrHPV) infection in different age groups of cytologically selected women from the
Zagreb region, and to evaluate the frequency and results of repeat hrHPV testing. During a one-year study period (November
2005 to November 2006), a total of 3,440 cervical samples from women attending gynecological services of public
and private health care systems were received. They were tested for 13 hrHPV genotypes by the polymerase chain reaction
based AMPLICOR HPV test (Roche Molecular Systems). The overall prevalence of hrHPV was 34.6%.Most samples were
obtained from women aged 21–30 years (44.2%), followed by the 31–40 (27.6%), 41–50 (15.7%), 51–60 (5.3%) and ³61
(2.4%) age groups. Out of 3,227 cervical samples obtained from women of known age, 4.9% were obtained from the group
of girls younger than 21, in which the highest prevalence of hrHPV (49.4%) was found. A similar prevalence was observed
in women aged 21–30 (45.1%). The prevalence gradually decreased with age. During the study period, repeat
hrHPV testing was performed in samples from 66 women at different intervals. Out of 28 women that were hrHPV negative
on initial testing, only five women turned positive on repeat testing. Out of 38 women that were positive on initial
testing, in one-third hrHPV could not be detected on repeat testing. As expected, hrHPV infection was highly prevalent in
female adolescents and young women. Further investigation on repeat hrHPV testing is needed to assess virus clearance
and rate of newly acquired infection.
Ključne riječi
High-risk human papillomavirus (hrHPV); prevalence; AMPLICOR HPV Test; repeat hrHPV testing
Hrčak ID:
27458
URI
Datum izdavanja:
13.4.2007.
Posjeta: 1.338 *