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Evaluation of coronary artery and immunologic status in post-COVID-19 children in Sarajevo

Senka Mesihović-Dinarević ; Academy of Arts and Sciences of Bosnia and Herzegovina, Eurofarm Center Polyclinic, Department of Pediatrics, Sarajevo, Bosnia and Herzegovina
Jasminka Prguda-Mujić ; Eurofarm Center Polyclinic, Clinical Laboratory Department, Sarajevo, Bosnia and Herzegovina
Timur Šečić ; Eurofarm Center Polyclinic, Department of Pediatrics, Sarajevo, Bosnia and Herzegovina

Puni tekst: hrvatski pdf 1.395 Kb

str. 153-157

preuzimanja: 76


Puni tekst: engleski pdf 1.395 Kb

str. 153-157

preuzimanja: 87



Introduction: Although evidence has demonstrated that SARS-COV-2 primarily affects the upper respiratory tract, other systems are also involved such as gastrointestinal and cardiovascular system. At present, there is insufficient data on cardiovascular and immunologic involvement in COVID-19 paediatric patients. Patients and Methods: This study evaluated 70 children previously healthy or with no pre-existing heart disease from Sarajevo with positive post-COVID history. Detailed cardiovascular examination was performed, with parameters of body weight, height, oxygen saturation, pulse, blood pressure, electrocardiogram (ECG), 24hrs Holter ECG, echocardiography. Laboratory tests included values of polymerase chain reaction (PCR) and SARS-COV-2 immunoglobulin G /IgG/ and immunoglobulin M /IgM/, CBC /complete blood count/, creatinine phosphokinase myofibrilae /CPKMB/, creatinine phosphokinase/CPK/, lactate dehydrogenase /LDH/, liver enzymes, D dimer, C reactive protein/CRP/ and urine. Results: Majority of children (64.3%) were asymptomatic. ECG was normal in relation to patients’ age, except in eight patients (intermittent palpitations on exertion): short
PR interval, so in 24hrs ECG Holter there was no significant arrhythmias except incomplete right branch block / IRBB/ in 12%, monofocal ventricular ectopicextrasystole /VES/ in 15%. Echocardiogram was normal in all patients with normal ejection fraction of the left ventricle, no pericardial effusion, vegetations or thrombus was detected. Mean diameter of coronary arteries right /RCA/ and left /LCA/ ranged from 1.98 mm to LCA 2.09 mm except in one symptomatic patient a diameter of left coronary artery /LCA/ was enlarged up to 3.8 mm. The concentration levels of COVID-19 IgG showed a statistical significance when compared between younger and older age groups in examined children (p < 0.05; p = 0.043). Conclusion: Cardiovascular evaluation should always be an option in post-COVID patients. Immunological assessment is necessary in post-COVID patients in order to gain a further understanding of patient’s status,

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Podaci na drugim jezicima: hrvatski

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