Uvodnik
https://doi.org/10.3325/cmj.2021.62.307
The physiology and pathophysiology of cerebrospinal fluid: new evidence
Marijan Klarica
; Department of Pharmacology and Croatian Institute for Brain Research, Zagreb University School of Medicine, Zagreb, Croatia
Milan Radoš
; Department of Pharmacology and Croatian Institute for Brain Research, Zagreb University School of Medicine, Zagreb, Croatia
Miroslav Vukić
; Department of Neurosurgery, Clinical Hospital Center Zagreb, Zagreb University School of Medicine, Zagreb, Croatia
Darko Orešković
; Department of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia
Sažetak
This issue of the Croatian Medical Journal is dedicated to advancements in the diagnostics and treatment of neurosurgical diseases. The issue features some of the articles that
were originally envisaged as lectures to be delivered at a
joint meeting of Croatian and Japanese Neurosurgical Societies on the topic of cerebrospinal fluid (CSF) physiology
and pathophysiology. The meeting entitled Physiology and
Pathophysiology of Cerebrospinal Fluid – New Evidence
was scheduled to be held in Vodice, Croatia, 2020, but was
postponed due to the COVID-19 pandemic. Two parts of
the meeting were planned: Cerebrospinal Fluid Volume
Regulation and Movement – Revision of Classical Concept
and Pathophysiology of Hydrocephalus – New Insights.
The first part was to be dedicated to the role of the choroid
plexus in physiology and pathophysiology. The classical
concept defines the choroid plexus as the main CSF source
(1,2), while a more recent theory, although not negating
the importance of the choroid plexus in CSF formation, attributes to this organ a much lesser role than previously
believed. The new theory postulates that what is important for CSF formation is the influx and exchange of fluid
at the capillary level in the central nervous system (1,3-7).
Furthermore, the first part of the meeting aimed to discuss
the research on the fate of molecules applied in different
parts of the CSF system with or without a blockade of the
transport systems in various animal models, from genetically modified mice fetuses (8,9) to large experimental animals (rabbits, cats, dog, pigs) (4-6,10). Mice fetus experi
Ključne riječi
Hrčak ID:
278143
URI
Datum izdavanja:
26.8.2021.
Posjeta: 421 *