Izvorni znanstveni članak
https://doi.org/10.3325/cmj.2021.62.310
18F-FET and 18F-choline PET-CT in patients with MRI-suspected low-grade gliomas: a pilot study
Ana Mišir Krpan
; Department of Oncology, University Hospital Center Zagreb, Zagreb University School of Medicine, Zagreb, Croatia
Marina Hodolič
; Nuclear Medicine Research Department, IASON, Graz, Austria
Anja Tea Golubić
; Department of Nuclear Medicine and Radiation Protection, University Hospital Center Zagreb, Zagreb, Croatia
Maja Baučić
; Department of Oncology, University Hospital Center Zagreb, Croatia
Jakob Nemir
; Department of Neurosurgery, University Hospital Center Zagreb, Zagreb, Croatia
Goran Mrak
; Department of Neurosurgery, University Hospital Center Zagreb, Zagreb, Croatia
Marijan Žuvić
; Department of Nuclear Medicine and Radiation Protection, University Hospital Center Zagreb, Zagreb, Croatia
Dražen Huić
; Department of Nuclear Medicine and Radiation Protection, University Hospital Center Zagreb, Zagreb, Croatia
Sažetak
Aim To investigate the diagnostic accuracy of O-(2-[18F]-
fluoroethyl)-L-tyrosine (18F-FET) and fluoromethyl-(18F)-
dimethyl-2-hydroxyethyl-ammonium chloride (18F-FCH)
computed tomography (CT) in patients with primary lowgrade gliomas (LGG).
Methods The study enrolled patients with magnetic resonance imaging (MRI)-suspected LGG. Patients underwent
both 18F-FET and 18F-FCH positron emission tomography
(PET)-CT. Brain PET-CT was performed according to standard protocol – 20 minutes after intravenous injection of
185 MBq of 18F-FET and 185 MBq of 18F-FCH PET. Surgery
and pathohistological diagnosis were performed in the
next two weeks.
Results We observed significantly better concordance between tumor histology and 18F-FET PET (weighted Kappa
0.74) compared with both 18F-FCH (weighted Kappa 0.15)
and MRI (weighted Kappa 0.00). Tumor histology was significantly associated with 18F-FET (odds ratio 12.87; 95%
confidence interval [CI], 0.49-333.70; P=0.013, logistic regression analysis). Receiver operating characteristic curve
analysis comparing 18F-FCH (area under the curve [AUC]
0.625, 95% CI 0.298-0.884) and 18F-FET (AUC 0.833, 95% CI
0.499-0.982) showed better diagnostic properties of 18F-FET
(AUC difference 0.208, 95% CI -0.145 to 0.562, P=0.248).
Conclusion Performing PET-CT in patients with newly diagnosed LGG should be preceded by a selection of an appropriate radiopharmaceutical. 18F-FET seems to be more
accurate than 18F-FCH in the LGG diagnosis
Ključne riječi
Hrčak ID:
278144
URI
Datum izdavanja:
26.8.2021.
Posjeta: 345 *