Skoči na glavni sadržaj

Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, Vol. 552 No. 58-59, 2022.

Pregledni rad

Melatonin therapy in chronic pain syndrome

Sanja Toljan
Vida Demarin

Puni tekst: engleski pdf 205 Kb

str. 82-87

preuzimanja: 368

citiraj

Sažetak

Melatonin is a hormone secreted 80% by epiphysis and 20% by extrapineal structures. It performs several functions including chronobiotic, antioxidant, oncostatic, immune modulating, normo- thermal, and anxiolytic functions.There are numorouse studies demonstrating melatonin efficacy in relation to chronic pain syndromes. The present paper reviews the studies on melatonin use in various forms of headaches, and chronic back pain.The paper discusses the possible mechanisms of analgesia. Circadian rhythm normalization results in sleep improvement, which is disordered in chronic pain syndromes,hence there is evidence of melatonin-independent analgesic effect involving melatonin receptors.

Ključne riječi

Melatonin; Chronic pain; Headache, Migraine; Tension type headache; Cluster headache; Low back pain;

Hrčak ID:

280803

URI

https://hrcak.srce.hr/280803

Datum izdavanja:

30.6.2022.

Posjeta: 626 *