Izvorni znanstveni članak
Comparison of Digital Rectal Examination and Prostate Specific Antigen in Early Detection of Prostate Cancer
Josip Galić
Ivan Karner
Ljiljana Ćenan
Antun Tucak
Ivana Hegeduš
Joško Pasini
Marijana Bilandžija-Peranović
Slobodan Mihaljević
Sažetak
This study compares the value of digital rectal examination (DRE) and prostate specific
antigen (PSA) determination in the detection of prostate cancer. 1,000 men aged
50 from the Osijek surroundings were examined. The subjects with prostatitis were excluded
from the study. The subjects with elevated concentration of total prostate specific
antigen and/or digital rectal examination suspect of carcinoma underwent prostate biopsy.
The rate of prostate cancer detection showed to be 3.3% for PSA > 4 ng/ml, 2% for
abnormal finding of DRE, and 3.7% for combination of the two methods. Out of 35 patients
with prostate cancer detected, 19 had suspect DRE finding and 32 had PSA exceeding
4 ng/ml. Thus, PSA pointed to the diagnosis of prostate cancer in 91.4%, and
abnormal finding of DRE in 54.2% of cases, the difference being statistically significant.
The positive predictive value was 48.7% for abnormal finding of DRE, 47% for
PSA > 4 ng/ml, and 80.0% for the combination of both. Although PSA determination
detected a considerable proportion of tumors missed on DRE, the former alone was found
to be insufficient as a screening method because of its inadequate sensitivity. When combined
with digital rectal examination, the probability of prostate cancer detection increased
considerably.
Ključne riječi
prostate cancer; prostate specific antigen; early detection
Hrčak ID:
28120
URI
Datum izdavanja:
26.6.2003.
Posjeta: 1.779 *