Pregledni rad
Systemic Therapies for Advanced Basal Cell and Cutaneous Squamous Cell Carcinomas: Novel Targeted Therapies and Immunotherapies
Mirela Krišto
orcid.org/0000-0002-7945-1888
; Department of Dermatology and Venereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Mirna Šitum
; Department of Dermatology and Venereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia
Romana Čeović
; Department of Dermatovenereology, University Hospital Center Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia
Sažetak
Nonmelanoma skin cancers (NMSC), basal cell carcinoma
(BCC), and cutaneous squamous cell carcinoma (cSCC) are the most
common malignancies worldwide with a prevalence of epidemic proportions and continually rising global incidence rates, associated with
increased morbidity rates and significant economic burden of their
management. Although treatable cancers with low rates of metastasis
and mortality, NMSCs reach an incurable state in small proportion of
patients, becoming advanced, unresectable, or metastatic. Until recent
years, patients with these conditions were considered for palliative radiotherapy and/or classical chemotherapies, which offer modest clinical benefit. Based on better understanding of the pathogenesis of these
cancers, novel targeted therapies have been developed. We review novel
systemic approaches for the treatment of aggressive forms of BCCs and
cSCCs, with special emphasis on approved targeted molecular therapies
and immunotherapies
Ključne riječi
Hrčak ID:
281275
URI
Datum izdavanja:
16.7.2020.
Posjeta: 255 *