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A Study of Replacement of Timolol-Pilocarpine with Latanoprost in Pseudoexfoliation Glaucoma
Lovro Bojić
Zdravko Mandić
Katija Novak-Lauš
Zlatko Sonicki
Deni Karelović
Sažetak
The aim of the study was to evaluate the efficacy of replacing current dual local therapy
(timolol and pilocarpine) with latanoprost 0.005% in 71 pseudoexfoliation glaucoma
patients with controlled intraocular pressure (IOP). 39 patients switched to latanoprost
0.005%) and 32 patients continued timolol-pilocarpine therapy. Mean diurnal
(IOP) was measured at baseline, after 0.5, 1, 3 and 6 months of treatment. After 6 months
38 patients with latanoprost and 30 patients with timolol-pilocarpine had completed
the study. At baseline the mean diurnal IOP was 20.4±2.0 mmHg for patients in latanoprost
treatment group and 21.4±2.1 mmHg for patients in timolol- pilocarpine group.
At the end of the study, after 6 months of treatment, the mean diurnal IOP values were
16.6±2.4 and 17.9±2.0 mmHg respectively. IOP was statistically significantly reduced
from baseline (p<0.001). The mean diurnal IOP change from baseline was –3.3±0.5 mmHg
(mean±SEM, ANCOVA) for the patients treated with latanoprost and –3.2±0.4 mmHg
for the patients treated with timolol+pilocarpine. This difference in IOP reduction between
groups was not statistically significant (z=0.69; p= 0.49). This study showed that
combination therapy (timolol plus pilocarpine) in pseudoexfoliation glaucoma can effectively
be replaced by latanoprost monotherapy.
Ključne riječi
latanoprost; timolol-pilocarpine; replacement; glaucoma
Hrčak ID:
28161
URI
Datum izdavanja:
15.12.2003.
Posjeta: 1.145 *